EFFECTS OF DRUG THERAPY OF VISCERAL LEISHMANIASIS ON SERUM LEVEL OF IFN-GAMMA, IL-10 AND IL-12 IN VISCERAL LEISHMANIASIS PATIENTS

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KHOUSHDEL A.; ALBORZI A.A.V.; RASOULI MANOUCHEHR; TAHERI ELHAM

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Journal: Zahedan Journal of Research in Medical Sciences Year:2008 | Volume:10 | Issue:1 Page(s): 9-16

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Information Journal Paper

Title

EFFECTS OF DRUG THERAPY OF VISCERAL LEISHMANIASIS ON SERUM LEVEL OF IFN-GAMMA, IL-10 AND IL-12 IN VISCERAL LEISHMANIASIS PATIENTS

Author(s)

KHOUSHDEL A. | ALBORZI A.A.V. | RASOULI MANOUCHEHR | TAHERI ELHAM | Issue Writer Certificate

Keywords

VISCERAL LEISHMANIOSISQ3

CYTOKINEQ2

IFN-GAMMAQ3

IL-10Q2

IL-12Q3

Abstract

Background: Leishmaniosis has remained a serious public health problem in several parts of the developing world. Effective prophylacyic measurements are hampered by imprecise understanding of different aspects of the disease, including its immunoregulation. A better understanding of immunoregulation in human VISCERAL LEISHMANIOSIS may be useful both for designing and evaluating immunoprophylaxis.Materials and Methods: This before-after interventional study investigated immunoregulatory mechanisms among 32 patients with visceral leishmaniasis in Shiraz (Iran) in 2007. The plasma CYTOKINE (IFN-gamma, IL-10 and IL-12) levels of participants were measured before, during active disease and at different periods up to 2 months after treatment.Results: Elevated plasma levels of IFN-g, IL-10 and IL-12 which were observed during active disease, decreased significantly after treatment. The main candidate for blunting IFN-g activity seems to be IL-10, since the level of this CYTOKINE which highly elevated in plasma decreased sharply after treatment.Discussion: Results suggest that IFN-g and IL-10 are the molecules most likely involved in determining fate of the disease. After treatment, there is a long delay before the immune profile returns to its normal level which precludes using plasma CYTOKINE levels as criteria for certain cure diagnosis of the disease.

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APA: Copy

KHOUSHDEL, A., ALBORZI, A.A.V., RASOULI, MANOUCHEHR, & TAHERI, ELHAM. (2008). EFFECTS OF DRUG THERAPY OF VISCERAL LEISHMANIASIS ON SERUM LEVEL OF IFN-GAMMA, IL-10 AND IL-12 IN VISCERAL LEISHMANIASIS PATIENTS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 10(1), 9-16. SID. https://sid.ir/paper/84428/en

Vancouver: Copy

KHOUSHDEL A., ALBORZI A.A.V., RASOULI MANOUCHEHR, TAHERI ELHAM. EFFECTS OF DRUG THERAPY OF VISCERAL LEISHMANIASIS ON SERUM LEVEL OF IFN-GAMMA, IL-10 AND IL-12 IN VISCERAL LEISHMANIASIS PATIENTS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2008;10(1):9-16. Available from: https://sid.ir/paper/84428/en

IEEE: Copy

A. KHOUSHDEL, A.A.V. ALBORZI, MANOUCHEHR RASOULI, and ELHAM TAHERI, “EFFECTS OF DRUG THERAPY OF VISCERAL LEISHMANIASIS ON SERUM LEVEL OF IFN-GAMMA, IL-10 AND IL-12 IN VISCERAL LEISHMANIASIS PATIENTS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 10, no. 1, pp. 9–16, 2008, [Online]. Available: https://sid.ir/paper/84428/en

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