EVALUATION OF THE EFFICACYOF AMINOLEVULINIC ACID-DEPENDENT PHOTODYNAMIC THERAPY ON MELANOMA CANCER CELLS TREATED WITH TOCOPHEROL SUCCINATE (IN-VITRO)

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KOUCHESFAHANI HOMA; PARIVAR KAZEM; NABIUNI MOHAMMAD; MOHAMMADI SARDOO MOHADDESE

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Journal: Zahedan Journal of Research in Medical Sciences Year:2012 | Volume:13 | Issue:8 Page(s): 1-7

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Title

EVALUATION OF THE EFFICACYOF AMINOLEVULINIC ACID-DEPENDENT PHOTODYNAMIC THERAPY ON MELANOMA CANCER CELLS TREATED WITH TOCOPHEROL SUCCINATE (IN-VITRO)

Author(s)

KOUCHESFAHANI HOMA | PARIVAR KAZEM | NABIUNI MOHAMMAD | MOHAMMADI SARDOO MOHADDESE | Issue Writer Certificate

Keywords

PHOTODYNAMIC THERAPYQ2

AMINOLEVULINIC ACIDQ2

TOCOPHEROL SUCCINATEQ2

MELANOMAQ2

Abstract

Background: PHOTODYNAMIC THERAPY (PDT) using 5-aminolevulinic acid (ALA) to produce an intracellular photo-sensitizer, a protoporphyrin molecule IX (PPIX) which absorbs light and targets cells, is a promising cancer treatment. Unfortunately, treatment failures are still a common occurrence when ALA is used. In this study, in order to enhance the efficacy of ALA-dependent PHOTODYNAMIC THERAPY, the effects of PHOTODYNAMIC THERAPY on MELANOMA cancer cells were studied after treating them with TOCOPHEROL SUCCINATE.Materials and Methods: In this experimental study MELANOMA cells were cultured in RPMI 1640 medium for 24 h. then, cells were treated with TOCOPHEROL SUCCINATE (6mm/ml). After 48 and 72 hours, the mediums were replaced by serum-free medium in the darkness, with ALA, 0.1mg/ml and then cells incubated for 4h. After that, cells were irradiated by using Nd: YAG laser (532 nm). After 24h, cell survival was measured by the MTT assay.Results: Twenty-four hours after PDT, among compared groups, pretreated cells with TOCOPHEROL SUCCINATE showed significant lower cell viability than control group.Conclusion: Induction of differentiation by using TOCOPHEROL SUCCINATE augmented intracellular PPIX accumulation in cells treated with ALA. Therefore phototoxic cell death after exposure to 532nm light enhances significantly in TOCOPHEROL SUCCINATE-pretreated cells. This study suggests that TOCOPHEROL SUCCINATE may act as a biological enhancer of ALA based PHOTODYNAMIC THERAPY.

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APA: Copy

KOUCHESFAHANI, HOMA, PARIVAR, KAZEM, NABIUNI, MOHAMMAD, & MOHAMMADI SARDOO, MOHADDESE. (2012). EVALUATION OF THE EFFICACYOF AMINOLEVULINIC ACID-DEPENDENT PHOTODYNAMIC THERAPY ON MELANOMA CANCER CELLS TREATED WITH TOCOPHEROL SUCCINATE (IN-VITRO). ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 13(8), 1-7. SID. https://sid.ir/paper/84539/en

Vancouver: Copy

KOUCHESFAHANI HOMA, PARIVAR KAZEM, NABIUNI MOHAMMAD, MOHAMMADI SARDOO MOHADDESE. EVALUATION OF THE EFFICACYOF AMINOLEVULINIC ACID-DEPENDENT PHOTODYNAMIC THERAPY ON MELANOMA CANCER CELLS TREATED WITH TOCOPHEROL SUCCINATE (IN-VITRO). ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2012;13(8):1-7. Available from: https://sid.ir/paper/84539/en

IEEE: Copy

HOMA KOUCHESFAHANI, KAZEM PARIVAR, MOHAMMAD NABIUNI, and MOHADDESE MOHAMMADI SARDOO, “EVALUATION OF THE EFFICACYOF AMINOLEVULINIC ACID-DEPENDENT PHOTODYNAMIC THERAPY ON MELANOMA CANCER CELLS TREATED WITH TOCOPHEROL SUCCINATE (IN-VITRO),” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 13, no. 8, pp. 1–7, 2012, [Online]. Available: https://sid.ir/paper/84539/en

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