EVALUATION THE EFFECT OF TOPICAL AND SYSTEMIC CELECOXIB ON SERUM ANTIOXIDANT IN INDUCTION OF TONGUE NEOPLASM IN RAT

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ARBABI KALATI F.; MESGARI ABBASI M.; AKBARI NARGES

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Journal: Zahedan Journal of Research in Medical Sciences Year:2011 | Volume:12 | Issue:4 Page(s): 11-16

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Title

EVALUATION THE EFFECT OF TOPICAL AND SYSTEMIC CELECOXIB ON SERUM ANTIOXIDANT IN INDUCTION OF TONGUE NEOPLASM IN RAT

Author(s)

ARBABI KALATI F. | MESGARI ABBASI M. | AKBARI NARGES | Issue Writer Certificate

Keywords

ORAL CANCERQ3

CELECOXIBQ2

ANTIOXIDANTQ2

Abstract

Background: ORAL CANCER is one of the ten most frequent cancers worldwide. Reactive oxygen species (ROS), may play a key role in human cancer development. Inflammation occurs in cancers and increases oxidative stress agent COX2 over expression in oral premalignant lesions. Several studies showed COX2 inhibitors con improve ANTIOXIDANT system. The aim of this study is the evaluation the effect of topical and systemic CELECOXIB on serum ANTIOXIDANT in induction of tongue neoplasm in rat.Materials and Method: Fifty male Sprague Dawley adult 3-3.5 months' old rats were used as animal model in this study. The tongue SCC was induced by a daily administration of 30 ppm 4-nitroquinoline 1-oxide (4-NQO), in drinking water, for 8 months. The rats in case groups received dietary or topical CCB. CCB powder was added to powdered basal diet and e ach rat received CCB with daily food. Adhesive Gels were prepared by mixing the base plasty with oral paste including two different dose of CCB. These groups include: group A» 30 ppm 4-NQO treatment; group B» 30 ppm 4- NQO+dietary CCB treatment; group C» 30 ppm 4-NQO+topical low dose CCB treatment; group D» 30 ppm 4NQO+high dose topical CCB treatment and group E» dietary CCB as control+water.Results: Statistical analysis showed significant differens between groups in total ANTIOXIDANT, hemoglobin and nutrophilic count.

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APA: Copy

ARBABI KALATI, F., MESGARI ABBASI, M., & AKBARI, NARGES. (2011). EVALUATION THE EFFECT OF TOPICAL AND SYSTEMIC CELECOXIB ON SERUM ANTIOXIDANT IN INDUCTION OF TONGUE NEOPLASM IN RAT. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 12(4), 11-16. SID. https://sid.ir/paper/84557/en

Vancouver: Copy

ARBABI KALATI F., MESGARI ABBASI M., AKBARI NARGES. EVALUATION THE EFFECT OF TOPICAL AND SYSTEMIC CELECOXIB ON SERUM ANTIOXIDANT IN INDUCTION OF TONGUE NEOPLASM IN RAT. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2011;12(4):11-16. Available from: https://sid.ir/paper/84557/en

IEEE: Copy

F. ARBABI KALATI, M. MESGARI ABBASI, and NARGES AKBARI, “EVALUATION THE EFFECT OF TOPICAL AND SYSTEMIC CELECOXIB ON SERUM ANTIOXIDANT IN INDUCTION OF TONGUE NEOPLASM IN RAT,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 12, no. 4, pp. 11–16, 2011, [Online]. Available: https://sid.ir/paper/84557/en

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