COMBINED THERAPY WITH DESFERAL AND DEFERIPRONE IN IMPROVEMENT OF HEART FUNCTION IN THALASSEMIC PATIENTS

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NOURI N.M.; ESHGHI P.; SHAHRAMIAN I.

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Journal: Zahedan Journal of Research in Medical Sciences Year:2010 | Volume:11 | Issue:4 Page(s): 35-42

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Title

COMBINED THERAPY WITH DESFERAL AND DEFERIPRONE IN IMPROVEMENT OF HEART FUNCTION IN THALASSEMIC PATIENTS

Author(s)

NOURI N.M. | ESHGHI P. | SHAHRAMIAN I. | Issue Writer Certificate

Keywords

MAJOR BETA THALASSEMIAQ3

ECHOCARDIOGRAPHYQ4

DESFERALQ3

DEFERIPRONEQ3

Abstract

Background: Cardiac complications due to iron overload are the most common causes of death in patients with major thalassemia. This study assessed the efficacy of iron chelating by DESFERAL-L1 in improvement of cardiac function in patients with major thalassemia. Methods and Materials: Patients older than 8 years old with major thalassemia that were admitted to hematology ward of Ali-e-Asghar hospital of Zahedan in 2005-2006 and had lower than normal diastolic indices in annual ECHOCARDIOGRAPHY were considered as study population. During primary tests, indices of diastolic function of left and right hearts were calculated, using ECHOCARDIOGRAPHY with 2D, M-mode and Doppler then the patients were placed on a combination of DESFERAL (30- 40mg/kg/day two nights per week) and L1 (deferiprone) (75mg/kg/day, three times a day). At the end of the study, cardiac indices were calculated again. Data were using SPSS software and paired t-test and P<0.05 was considered as significant level. Results: Of 38 patients, who were treated with a combination of DESFERAL-L1, 19 were female with the mean age of 16.9±3.1 and 18 were male with the mean age of 17.3±2.6 years. Diastolic indices of right ventricle had no significant difference before and after treatment except PET/ET which decreased significantly after treatment (P<0.05). Of diastolic indices of left ventricule peak-Evelocity and IVRT and E/A ratio decreased significantly after treatment (P<0.05). The difference of peak-A-velocity before and after treatment was not significant (P>0.05). Systolic indices of left ventricule increased significantly after treatment (P<0.05).Conclusion: In this study, after one year of treatment with a combination of DESFERAL-L1 in patients with major thalassemia, ECHOCARDIOGRAPHY showed improvement in left heart systolic and diastolic function. This combination therapy prevented progression of right ventricular diastolic function abnormality.

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APA: Copy

NOURI, N.M., ESHGHI, P., & SHAHRAMIAN, I.. (2010). COMBINED THERAPY WITH DESFERAL AND DEFERIPRONE IN IMPROVEMENT OF HEART FUNCTION IN THALASSEMIC PATIENTS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 11(4), 35-42. SID. https://sid.ir/paper/84594/en

Vancouver: Copy

NOURI N.M., ESHGHI P., SHAHRAMIAN I.. COMBINED THERAPY WITH DESFERAL AND DEFERIPRONE IN IMPROVEMENT OF HEART FUNCTION IN THALASSEMIC PATIENTS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2010;11(4):35-42. Available from: https://sid.ir/paper/84594/en

IEEE: Copy

N.M. NOURI, P. ESHGHI, and I. SHAHRAMIAN, “COMBINED THERAPY WITH DESFERAL AND DEFERIPRONE IN IMPROVEMENT OF HEART FUNCTION IN THALASSEMIC PATIENTS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 11, no. 4, pp. 35–42, 2010, [Online]. Available: https://sid.ir/paper/84594/en

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