IN VITRO AND IN VIVO EVALUATION OF THERAPEUTIC EFFECTS OF VINCA MAJOR ALKALOIDS ON LEISHMANIA MAJOR

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ASMAR M.; FARAHMAND BEYGI MAHIN; AGHIGHI Z.; GHAEMI N.; AYAT ELAHI A.

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Journal: JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH Year:2002 | Volume:1 | Issue:2 Page(s): 1-8

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Title

IN VITRO AND IN VIVO EVALUATION OF THERAPEUTIC EFFECTS OF VINCA MAJOR ALKALOIDS ON LEISHMANIA MAJOR

Author(s)

Keywords

VINCA ALKALOIDQ4

LEISHMANIA MAJORQ4

THERAPEUTIC EFFECTQ4

BALB/CQ4

Abstract

Leishmaniasis affects 1.5-2 million people annually and has been recognized as a major public health problem by the World Organization.In Iran the incidence rate of the disease among school children in Ardestan province was 3.2 per thousand. As no effective vaccine has been found yet, control of the disease depends on effective drug therapy. The pentavalent anitmonials (pentostam and glucantime) are the current drugs of choice,but their use has been associated with side effects and a certain degree of toxicity. Furthermore, resistance towards these medications is not uncommon. For these reasons we studied the effectiveness of Vinca major alkaloids in treating LEISHMANIA MAJOR infections both in vitro and invivo. Vinca has been used for centuries as a traditional remedy in the treatment of various diseases.The effectiveness of different concentrations of Vinca on LEISHMANIA MAJOR promastigotes was evaluated and the results showed a significant decrease in the number of promastigotes with higher concentrations and increasing exposure times (P<0.005).Results of in vivo trials showed that intralesional injections of purified extracts in chloroffomic phase induced a significant decrease in the mean lesion diameter in BALB/C mice compared to the untreated group.

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مروری بر روشهای نوین درمان لیشمانیوز جلدی در انسان

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APA: Copy

ASMAR, M., FARAHMAND BEYGI, MAHIN, AGHIGHI, Z., GHAEMI, N., & AYAT ELAHI, A.. (2002). IN VITRO AND IN VIVO EVALUATION OF THERAPEUTIC EFFECTS OF VINCA MAJOR ALKALOIDS ON LEISHMANIA MAJOR. JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH, 1(2), 1-8. SID. https://sid.ir/paper/85032/en

Vancouver: Copy

ASMAR M., FARAHMAND BEYGI MAHIN, AGHIGHI Z., GHAEMI N., AYAT ELAHI A.. IN VITRO AND IN VIVO EVALUATION OF THERAPEUTIC EFFECTS OF VINCA MAJOR ALKALOIDS ON LEISHMANIA MAJOR. JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH[Internet]. 2002;1(2):1-8. Available from: https://sid.ir/paper/85032/en

IEEE: Copy

M. ASMAR, MAHIN FARAHMAND BEYGI, Z. AGHIGHI, N. GHAEMI, and A. AYAT ELAHI, “IN VITRO AND IN VIVO EVALUATION OF THERAPEUTIC EFFECTS OF VINCA MAJOR ALKALOIDS ON LEISHMANIA MAJOR,” JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH, vol. 1, no. 2, pp. 1–8, 2002, [Online]. Available: https://sid.ir/paper/85032/en

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