EFFECT OF PISTACIA ATLANTICA HYDRO ALCOHOLIC EXTRACT WITH BONE MARROW- DERIVED STEM CELLS ON INDUCED KNEE OSTEOARTHRITIS IN RAT

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BORZOOEIAN GITI; TANIDEH NADER; LOTFI MEHRZAD; MOKHTARI MARAL; NAZEM HABIBOLLAH; SANI MAHSA; SALMAN NEZHAD MAHIN; KOOHI HOSSEINABADI OMID; DANESHI SAJAD

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Journal: IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY Year:2016 | Volume:14 | Issue:1 (54) Page(s): 30-41

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Title

EFFECT OF PISTACIA ATLANTICA HYDRO ALCOHOLIC EXTRACT WITH BONE MARROW- DERIVED STEM CELLS ON INDUCED KNEE OSTEOARTHRITIS IN RAT

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Keywords

OSTEOARTHRITISQ2

PISTACIA ATLANTICA HYDRO ALCOHOLIC EXTRACTQ2

BONE MARROW STEM CELLSQ2

CHONDROCYTEQ2

Abstract

Background: OSTEOARTHRITIS is a progressive joint disease. Mastic fruit has antioxidant and anti-inflammatory properties. BONE MARROW STEM CELLS have the ability to differentiate into CHONDROCYTE. The purpose of this study is to evaluate the effect of PISTACIA ATLANTICA HYDRO ALCOHOLIC EXTRACT with bone marrow- derived stem cells on induced knee OSTEOARTHRITIS in rat.Methods: 50 male Wistar rats were divided into 5 groups of 10. Then, under anesthesia on days zero and 3, fifty ml collagenase type 2 was injected in the left knee. After 10 weeks, OSTEOARTHRITIS was induced. The rats were divided into 5 groups: 1.control, 2.Pistacia atlantica hydro alcoholic extract therapy, 3.treatment by stem cell and PISTACIA ATLANTICA HYDRO ALCOHOLIC EXTRACT, 4.stem cell therapy alone and 5.treatment with hyalgan. After 12 weeks of treatment for OSTEOARTHRITIS, radiographic and histopathologic surveys and also measurement of antioxidant properties as MDA-TAC were performed.Results: After 12 weeks, histopathologic and radioghraphic evaluation revealed that results of the cell with extract group was significantly different compared to other treatment groups as well as the control group (p<0.05).there was also signified reduction in oxidative stress-based on biochemical evaluation of MDA-TAC in group with cell extracting ejection, compared with the control and also other treatment groups, based on biochemical evaluation of MDA-TAC in cell with extract group significant reduction in oxidative stress is observed compared to other treatment groups and control (p<0.05).Conclusions: It seems that PISTACIA ATLANTICA HYDRO ALCOHOLIC EXTRACT with bone marrow- derived stem cells are effective in knee cartilage repair.

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APA: Copy

BORZOOEIAN, GITI, TANIDEH, NADER, LOTFI, MEHRZAD, MOKHTARI, MARAL, NAZEM, HABIBOLLAH, SANI, MAHSA, SALMAN NEZHAD, MAHIN, KOOHI HOSSEINABADI, OMID, & DANESHI, SAJAD. (2016). EFFECT OF PISTACIA ATLANTICA HYDRO ALCOHOLIC EXTRACT WITH BONE MARROW- DERIVED STEM CELLS ON INDUCED KNEE OSTEOARTHRITIS IN RAT. IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, 14(1 (54) ), 30-41. SID. https://sid.ir/paper/85390/en

Vancouver: Copy

BORZOOEIAN GITI, TANIDEH NADER, LOTFI MEHRZAD, MOKHTARI MARAL, NAZEM HABIBOLLAH, SANI MAHSA, SALMAN NEZHAD MAHIN, KOOHI HOSSEINABADI OMID, DANESHI SAJAD. EFFECT OF PISTACIA ATLANTICA HYDRO ALCOHOLIC EXTRACT WITH BONE MARROW- DERIVED STEM CELLS ON INDUCED KNEE OSTEOARTHRITIS IN RAT. IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY[Internet]. 2016;14(1 (54) ):30-41. Available from: https://sid.ir/paper/85390/en

IEEE: Copy

GITI BORZOOEIAN, NADER TANIDEH, MEHRZAD LOTFI, MARAL MOKHTARI, HABIBOLLAH NAZEM, MAHSA SANI, MAHIN SALMAN NEZHAD, OMID KOOHI HOSSEINABADI, and SAJAD DANESHI, “EFFECT OF PISTACIA ATLANTICA HYDRO ALCOHOLIC EXTRACT WITH BONE MARROW- DERIVED STEM CELLS ON INDUCED KNEE OSTEOARTHRITIS IN RAT,” IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, vol. 14, no. 1 (54) , pp. 30–41, 2016, [Online]. Available: https://sid.ir/paper/85390/en

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