EFFECT OF INTRA-ARTICULAR HYALURONIC ACID OR METHYL PREDNISOLONE, OR ORAL ANTI-INFLAMMATORY DRUGS IN KNEE OSTEOARTHRITIS (A COMPARATIVE STUDY)

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ESMAEILIJAH A.A.; ABBASIAN M.R.; HOSSEINZADEH HAMID REZA; JAZAYERI SEYED MOHAMMAD; HASAS YEGANEH M.; MOHSENI N.

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Journal: IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY Year:2008 | Volume:6 | Issue:2 (22) Page(s): 74-80

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Title

EFFECT OF INTRA-ARTICULAR HYALURONIC ACID OR METHYL PREDNISOLONE, OR ORAL ANTI-INFLAMMATORY DRUGS IN KNEE OSTEOARTHRITIS (A COMPARATIVE STUDY)

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Keywords

OSTEOARTHRITISQ3

KNEEQ3

INJECTIONSQ3

INTRA-ARTICULARQ2

HYALURONIC ACIDQ2

KNEEQ2

Abstract

Background: OSTEOARTHRITIS is a relatively common ailment of human beings. The aim of this study is to compare the short-term effects of oral non-steroid anti-inflammatory medications with INTRA-ARTICULAR INJECTIONS of HYALURONIC ACID or Methyl Prednisolone acetate.Methods: In a clinical trial study, 40 female patients with moderate or severe KNEE OSTEOARTHRITIS received HYALURONIC ACID INTRA-ARTICULAR INJECTIONS. They were compared with 16 cases who had INTRA-ARTICULAR Prednisolone injection and 36 female patients who received non-steroid anti-inflammatory oral medication. The results were evaluated in 6 and 24 weeks by Visual Analogue Scale and Western Ontario & McMaster Universities (WOMAC) functional score. Results: Pain relief in 6 and 24 weeks post injection were 4.9 and 4.7 for HYALURONIC ACID, and 1.5 and 1.6 for Prednisolone. The figures for oral non-steroidal anti-inflammatory medication were 5.2 and 4.9 respectively. Subjective patient’s satisfaction was expressed in 28 (70%) of HYALURONIC ACID group and 16 (100%) of Prednisolone group.Conclusions: After 6 and 24 weeks following INTRA-ARTICULAR steroid injection in female patients with KNEE OSTEOARTHRITIS, pain relief and subjective patient satisfaction is more favorable compared to INTRA-ARTICULAR HYALURONIC ACID injection. These two are both more effective than oral anti-inflammatories. This statement does not include the potential side-effects of INTRA-ARTICULAR steroid injection in long-term.

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APA: Copy

ESMAEILIJAH, A.A., ABBASIAN, M.R., HOSSEINZADEH, HAMID REZA, JAZAYERI, SEYED MOHAMMAD, HASAS YEGANEH, M., & MOHSENI, N.. (2008). EFFECT OF INTRA-ARTICULAR HYALURONIC ACID OR METHYL PREDNISOLONE, OR ORAL ANTI-INFLAMMATORY DRUGS IN KNEE OSTEOARTHRITIS (A COMPARATIVE STUDY). IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, 6(2 (22)), 74-80. SID. https://sid.ir/paper/85461/en

Vancouver: Copy

ESMAEILIJAH A.A., ABBASIAN M.R., HOSSEINZADEH HAMID REZA, JAZAYERI SEYED MOHAMMAD, HASAS YEGANEH M., MOHSENI N.. EFFECT OF INTRA-ARTICULAR HYALURONIC ACID OR METHYL PREDNISOLONE, OR ORAL ANTI-INFLAMMATORY DRUGS IN KNEE OSTEOARTHRITIS (A COMPARATIVE STUDY). IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY[Internet]. 2008;6(2 (22)):74-80. Available from: https://sid.ir/paper/85461/en

IEEE: Copy

A.A. ESMAEILIJAH, M.R. ABBASIAN, HAMID REZA HOSSEINZADEH, SEYED MOHAMMAD JAZAYERI, M. HASAS YEGANEH, and N. MOHSENI, “EFFECT OF INTRA-ARTICULAR HYALURONIC ACID OR METHYL PREDNISOLONE, OR ORAL ANTI-INFLAMMATORY DRUGS IN KNEE OSTEOARTHRITIS (A COMPARATIVE STUDY),” IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, vol. 6, no. 2 (22), pp. 74–80, 2008, [Online]. Available: https://sid.ir/paper/85461/en

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