THE EVALUATION OF PARACLINCIAL SITUATION IN PATIENTS OF CHRONIC HEPATITIS B AFTER ONE YEAR TREATMENT WITH LAMIVUDINE

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ALAVIAN S.M.; HATAMI S.

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Journal Paper

Paper Information

Journal: GOVARESH JOURNAL Year:2002 | Volume:7 | Issue:37-38 Page(s): 33-37

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Title

THE EVALUATION OF PARACLINCIAL SITUATION IN PATIENTS OF CHRONIC HEPATITIS B AFTER ONE YEAR TREATMENT WITH LAMIVUDINE

Author(s)

ALAVIAN S.M. | HATAMI S. | | Issue Writer Certificate

Keywords

EFFICIENCYQ2

HEPATITIS BQ4

CHRONICQ3

LAMIVUDINEQ3

Abstract

Objective: In respect to prevalence of CHRONIC HEPATITIS B (CHB) and importance of its treatment as a preventive factor to community transmission of this disease, we designed this study to evaluate liver enzyme and virologic indexes after one year treatment with LAMIVUDINE.Methods: This research is a single group time series design from the quasi-experimental studies. Eighty CHB patients with elevated ALT, HbeAg or HBV DNA positive and liver histologic changes, whom reffered to Tehran Hepatitis Center (2001), were selected. The sequential liver enzyme test were performed at 0,3,6 and 12 month after start of treatment and also HbeAg or HBV DNA were evaluated at 0,6 and 12 month. HBV DNA was evaluated with qualitative Polymerase Chain Reaction (PCR).Results: Eight patients excluded for not to continue participation regularly. From 72 patients, 63 (87.5%) were male. The mean of patients age was 40.2. ALT and AST level decreased in 4 sequential times and both in 12 month were normal. These changes were significant by repeated measurement ANOVA (P<0.001). Also 66% of patients became HbeAg negative in 12 month and 77.7% became HBV DNA (PCR) negative (P<0.001). The relation between ALT decrease and history of Interferon therapy was not significant (P=0.64).Conclusion: In this study, we found that one year Lamivudin therapy in CHB, cause significant decrease in ALT and AST; it also causes much effect in both HbeAg positive and HbeAg negative patients. History of already Interferon therapy did not affect in response to LAMIVUDINE.

Cites

بررسی تاثیر برنامه خود مراقبتی بر کیفیت زندگی بیماران مبتلا به سیروز کبدی که به مرکز هپاتیت تهران در سال 1381 مراجعه کرده بودند

References

VIRAL HEPATITIS IN THE WORLD AND IRAN

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APA: Copy

ALAVIAN, S.M., & HATAMI, S.. (2002). THE EVALUATION OF PARACLINCIAL SITUATION IN PATIENTS OF CHRONIC HEPATITIS B AFTER ONE YEAR TREATMENT WITH LAMIVUDINE . GOVARESH JOURNAL, 7(37-38), 33-37. SID. https://sid.ir/paper/86075/en

Vancouver: Copy

ALAVIAN S.M., HATAMI S.. THE EVALUATION OF PARACLINCIAL SITUATION IN PATIENTS OF CHRONIC HEPATITIS B AFTER ONE YEAR TREATMENT WITH LAMIVUDINE . GOVARESH JOURNAL[Internet]. 2002;7(37-38):33-37. Available from: https://sid.ir/paper/86075/en

IEEE: Copy

S.M. ALAVIAN, and S. HATAMI, “THE EVALUATION OF PARACLINCIAL SITUATION IN PATIENTS OF CHRONIC HEPATITIS B AFTER ONE YEAR TREATMENT WITH LAMIVUDINE ,” GOVARESH JOURNAL, vol. 7, no. 37-38, pp. 33–37, 2002, [Online]. Available: https://sid.ir/paper/86075/en

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