THE PREVALENCE OF HEPATITIS B AND C AMONG THALASSEMIA MAJOR PATIENTS IN KERMAN, IRAN, AND THE ROLE OF TRANSFUSION IN INFECTION ACQUISITION

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ZAHEDI M.J.; ZAND V.; TAVAKOLI M.; HAJARIZADEH B.; ALAVIAN S.M.

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Journal: GOVARESH JOURNAL Year:2003 | Volume:8 | Issue:44 Page(s): 72-78

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Title

THE PREVALENCE OF HEPATITIS B AND C AMONG THALASSEMIA MAJOR PATIENTS IN KERMAN, IRAN, AND THE ROLE OF TRANSFUSION IN INFECTION ACQUISITION

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Keywords

THALASSEMIA MAJORQ3

HEPATITIS B VIRUSQ3

HEPATITIS C VIRUSQ3

BLOOD TRANSFUSIONQ3

Abstract

INTRODUCTION: Regular BLOOD TRANSFUSIONs for patients with THALASSEMIA MAJOR have improved their overall survival, but carry a definite risk of being infected with blood born viruses especially hepatitis Band C. Nowadays, it has remained as main health concern about these patients. In this study, we tried to define the prevalence rate of hepatitis Band C and survey the related risk factors among a group of thalassemic patients in Iran.METHODS: We evaluated 100 thalassemics in Kerman, Iran in July 2002. The initial data were recorded and the sera were tested for HBV seromarkers, anti-HCV Ab and anti-HIV Ab. Anti-HCV Ab was detected using ELlSA-2nd generation and confirmed by RIBA-2nd generation. Second samples tested to measure hemoglobin and serum ferritin levels.RESULTS: Thirty-one patients were anti-HCV-Ab (ELlSA) positive. In 11 cases the RIBA results were missed and among 20 cases remained, 14 patients were anti-HCV Ab (RIBA) positive. Six patients (6%) were HBs Ag positive and there was no anti-HIV positive case. Mean of patients' age, and transfusion duration were significantly higher in anti- HCV seropositive patients (p<0.001, p<0.001 respectively). Furthermore, HCV prevalence rate has significantly dropped after applying anti-HCV Ab screening in blood donors (22.4% vs. 0%, p=0.006), and there was no new infected case thereafter. There were no significant associations between anti-HCV Ab seropositivity and sex, vaccination against HBV, and family history of hepatitis. The mean of hemoglobin and serum ferritin did not differ between two groups.CONCLUSION: Hepatitis C prevalence rate is very high among thalassemics. Screening of blood donors seems to be able to decrease prevalence and incidence rate of HCV infection effectively.

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APA: Copy

ZAHEDI, M.J., ZAND, V., TAVAKOLI, M., HAJARIZADEH, B., & ALAVIAN, S.M.. (2003). THE PREVALENCE OF HEPATITIS B AND C AMONG THALASSEMIA MAJOR PATIENTS IN KERMAN, IRAN, AND THE ROLE OF TRANSFUSION IN INFECTION ACQUISITION. GOVARESH JOURNAL, 8(44), 72-78. SID. https://sid.ir/paper/86080/en

Vancouver: Copy

ZAHEDI M.J., ZAND V., TAVAKOLI M., HAJARIZADEH B., ALAVIAN S.M.. THE PREVALENCE OF HEPATITIS B AND C AMONG THALASSEMIA MAJOR PATIENTS IN KERMAN, IRAN, AND THE ROLE OF TRANSFUSION IN INFECTION ACQUISITION. GOVARESH JOURNAL[Internet]. 2003;8(44):72-78. Available from: https://sid.ir/paper/86080/en

IEEE: Copy

M.J. ZAHEDI, V. ZAND, M. TAVAKOLI, B. HAJARIZADEH, and S.M. ALAVIAN, “THE PREVALENCE OF HEPATITIS B AND C AMONG THALASSEMIA MAJOR PATIENTS IN KERMAN, IRAN, AND THE ROLE OF TRANSFUSION IN INFECTION ACQUISITION,” GOVARESH JOURNAL, vol. 8, no. 44, pp. 72–78, 2003, [Online]. Available: https://sid.ir/paper/86080/en

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