THE EFFECT OF FLUOXETINE IN PATIENTS WITH PAIN AND CONSTIPATION PREDOMINANT IRRITABLE BOWEL SYNDROME

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VAHEDI H.; MERAT SH.; RASHIDIOUN A.; GHODDOOSI A.R.; OLFATI G.; MALEKZADEH R.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: GOVARESH JOURNAL Year:2004 | Volume:9 | Issue:4 Page(s): 226-231

Download Full-Text

Persian Verion

View:

34,426

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF FLUOXETINE IN PATIENTS WITH PAIN AND CONSTIPATION PREDOMINANT IRRITABLE BOWEL SYNDROME

Author(s)

Keywords

INTESTINAL DISORDERSQ4

MOTILITY AND NERVE-GUT INTERACTIONSQ4

IRRITABLE BOWEL SYNDROMQ2

FLUOXETINEQ4

Abstract

Background: IRRITABLE BOWEL SYNDROMe (IBS) is the most common disorder diagnosed by gastroenterologists seen in about 40-50% of patients seeking care from a specialist. IBS has been treated with selective serotonin reuptake inhibitors, but there is not enough evidence from controlled trials for their effectiveness.Materials and Methods: The aim of the study was to compare the effects of FLUOXETINE and placebo in the treatment of pain and constipationpredominant IBS in a double-blind randomized controlled trial. Forty four cases meeting Rome II criteria for IBS with predominance of pain and constipation were included in this study. Organic causes were ruled out by detailed history, physical examination, laboratory tests, and colonoscopy. Participants were then randomly assigned to receive either FLUOXETINE or placebo for 12 weeks. Subjects were followed using a simple symptom score system during treatment and four weeks after termination of treatment.Results: FLUOXETINE was significantly more effective than placebo in decreasing abdominal discomfort, relieving feeling and sense of bloating, increasing frequency of bowel movements and decreasing consistency of stool. The total symptom score decreased from 10.7 to 2.8 in the FLUOXETINE group vs. 10.5 to 6.7 in controls (p<0.001). Conclusions: FLUOXETINE is an effective and well-tolerated short-term treatment for pain and constipation-predominant IBS.

Cites

No record.

References

No record.

Cite

APA: Copy

VAHEDI, H., MERAT, SH., RASHIDIOUN, A., GHODDOOSI, A.R., OLFATI, G., & MALEKZADEH, R.. (2004). THE EFFECT OF FLUOXETINE IN PATIENTS WITH PAIN AND CONSTIPATION PREDOMINANT IRRITABLE BOWEL SYNDROME. GOVARESH JOURNAL, 9(4), 226-231. SID. https://sid.ir/paper/86244/en

Vancouver: Copy

VAHEDI H., MERAT SH., RASHIDIOUN A., GHODDOOSI A.R., OLFATI G., MALEKZADEH R.. THE EFFECT OF FLUOXETINE IN PATIENTS WITH PAIN AND CONSTIPATION PREDOMINANT IRRITABLE BOWEL SYNDROME. GOVARESH JOURNAL[Internet]. 2004;9(4):226-231. Available from: https://sid.ir/paper/86244/en

IEEE: Copy

H. VAHEDI, SH. MERAT, A. RASHIDIOUN, A.R. GHODDOOSI, G. OLFATI, and R. MALEKZADEH, “THE EFFECT OF FLUOXETINE IN PATIENTS WITH PAIN AND CONSTIPATION PREDOMINANT IRRITABLE BOWEL SYNDROME,” GOVARESH JOURNAL, vol. 9, no. 4, pp. 226–231, 2004, [Online]. Available: https://sid.ir/paper/86244/en

Related Journal Papers