CANCER-GENETICS EPIDEMIOLOGY AND GENETICS INVESTIGATION IN COLORECTAL CARCINOMAS: DIRECTIONS TOWARDS PREVENTION

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MAHDIPOUR P.; ATRI M.; NASERZADEH H.; HASHEMI S.; TAVOUSI GH.R

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Journal: GOVARESH JOURNAL Year:2002 | Volume:6 | Issue:33-34 Page(s): 115-119

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Title

CANCER-GENETICS EPIDEMIOLOGY AND GENETICS INVESTIGATION IN COLORECTAL CARCINOMAS: DIRECTIONS TOWARDS PREVENTION

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Abstract

Introduction: Carcinomas of the colon and rectum are the second most common cause of death due to malignancy. Risk factors are categorized as: Low risk: age 50 years, no family history of early onset colorectal cancer (CRC) or personal history of high risk disease. Average risk: age>50 years and asymptomatic. High risk: personal history and family history of CRC and associated syndromes. Research into the genetics of CRC is vital for both the potential population and for the genetically mediated therapies which could lead to early detection, and improved surveillance of the disease. These could possibly improve the outlook of colorectal cancers.CRC is a disease in which 15% to 20% of cases are inherited. Familial adenomatous polyposis and hereditary non-polyposis CRC represent the two most common forms of inherited CRC. Mutation of APC (11307K) is associated with CRC in certain Jewish populations. APC, K-ras, DCC, and P53 mutations occur and vary in specific types of CRC and specific lesions of CR. APC mutations are sufficient for colorectal tumors to grow to about 1 cm in diameter, although chance mutations at other loci can provide the early colorectal adenomas with a selective advantage and some colorectal tumors may develop along a pathway not involving the APC-gene. The occurrence of CRC and brain tumors (Turcott's syndrome) and other cancers are important paradigms in the dual look, including the study of cancer genetic epidemiology and genetics in different populations.

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APA: Copy

MAHDIPOUR, P., ATRI, M., NASERZADEH, H., HASHEMI, S., & TAVOUSI, GH.R. (2002). CANCER-GENETICS EPIDEMIOLOGY AND GENETICS INVESTIGATION IN COLORECTAL CARCINOMAS: DIRECTIONS TOWARDS PREVENTION. GOVARESH JOURNAL, 6(33-34), 115-119. SID. https://sid.ir/paper/86258/en

Vancouver: Copy

MAHDIPOUR P., ATRI M., NASERZADEH H., HASHEMI S., TAVOUSI GH.R. CANCER-GENETICS EPIDEMIOLOGY AND GENETICS INVESTIGATION IN COLORECTAL CARCINOMAS: DIRECTIONS TOWARDS PREVENTION. GOVARESH JOURNAL[Internet]. 2002;6(33-34):115-119. Available from: https://sid.ir/paper/86258/en

IEEE: Copy

P. MAHDIPOUR, M. ATRI, H. NASERZADEH, S. HASHEMI, and GH.R TAVOUSI, “CANCER-GENETICS EPIDEMIOLOGY AND GENETICS INVESTIGATION IN COLORECTAL CARCINOMAS: DIRECTIONS TOWARDS PREVENTION,” GOVARESH JOURNAL, vol. 6, no. 33-34, pp. 115–119, 2002, [Online]. Available: https://sid.ir/paper/86258/en

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