THE PREVALENCE OF CELIAC DISEASE IN APPARENTLY HEALTHY IRANIAN BLOOD DONORS. SHOULD WE SCREEN HEALTHY POPULATION?

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SHAHBAZKHANI B.; MALEKZADEH R.; SOTOUDEH M.; FAYAZ MOGHADAM K.; ANSARI R.; ELAHIFAR A.; ROSTAMI K.

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Journal: GOVARESH JOURNAL Year:2001 | Volume:5 | Issue:29-30 Page(s): 131-134

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Title

THE PREVALENCE OF CELIAC DISEASE IN APPARENTLY HEALTHY IRANIAN BLOOD DONORS. SHOULD WE SCREEN HEALTHY POPULATION?

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Abstract

Background: There are no studies on the prevalence of celiac disease (CD) in either Iran or as far as we know on healthy population in Asian countries.Study design and methods: The aim of this study was to determine the prevalence of CD in Iranian healthy blood donors. Blood samples were obtained form 2000 apparently healthy blood donors at Tehran Blood Donation Center over a four months period form November 1998 through February 1999 Total serum IgA was measured in all and IgA deficient cases were excluded. All cases were analyzed for IgA-AGA test and those with positive results were tested on IgA-anti-endomysium (EMA) using immunofluorescence. All donors who had a positive serology for both AGA and EMA underwent small intestinal biopsy. The biopsy samples were classified according to revised Marsh criteria 1999. Results: Forty-nine cases showed positive IgA-AGA (38 males and 11 females, mean age 38.6 yrs). Of the 49 AGA-positive 12 cases showed positive EMA. All subjects with positive serology (both AGA and EMA) were found to have small bowel biopsies compatible with gluten sensitive enteropathy. Three of 12 had Marsh 1, 4/12 Marsh 11 and 5/12 showed a Marsh llla lesion.Conclusion: This study shows that the prevalence of gluten-sensitivity among apparently healthy Iranian blood donors is 1/166. This prevalence rate seems to be even higher than western countries. Despite immuno-histochemical abnormalities compatible with CD in our patients we did not treat them with gluten free diet, since they had no major clinical complaints. Although we recommend great awareness for detecting and treatment of symptomatic cases with atypical presentation, we discourage the screening of healthy population. Treatment strategy for atypicalgroup should be based on a good defined guideline and adequate data's.

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APA: Copy

SHAHBAZKHANI, B., MALEKZADEH, R., SOTOUDEH, M., FAYAZ MOGHADAM, K., ANSARI, R., ELAHIFAR, A., & ROSTAMI, K.. (2001). THE PREVALENCE OF CELIAC DISEASE IN APPARENTLY HEALTHY IRANIAN BLOOD DONORS. SHOULD WE SCREEN HEALTHY POPULATION?. GOVARESH JOURNAL, 5(29-30), 131-134. SID. https://sid.ir/paper/86279/en

Vancouver: Copy

SHAHBAZKHANI B., MALEKZADEH R., SOTOUDEH M., FAYAZ MOGHADAM K., ANSARI R., ELAHIFAR A., ROSTAMI K.. THE PREVALENCE OF CELIAC DISEASE IN APPARENTLY HEALTHY IRANIAN BLOOD DONORS. SHOULD WE SCREEN HEALTHY POPULATION?. GOVARESH JOURNAL[Internet]. 2001;5(29-30):131-134. Available from: https://sid.ir/paper/86279/en

IEEE: Copy

B. SHAHBAZKHANI, R. MALEKZADEH, M. SOTOUDEH, K. FAYAZ MOGHADAM, R. ANSARI, A. ELAHIFAR, and K. ROSTAMI, “THE PREVALENCE OF CELIAC DISEASE IN APPARENTLY HEALTHY IRANIAN BLOOD DONORS. SHOULD WE SCREEN HEALTHY POPULATION?,” GOVARESH JOURNAL, vol. 5, no. 29-30, pp. 131–134, 2001, [Online]. Available: https://sid.ir/paper/86279/en

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