Multiple Repeats of Helicobacter pylori CagA C-Terminal Motifs Predict the Risk of Gastric Cancer in Iran

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Sarrami Somaye; LATIFI NAVID SAEID; ZAHRI SABER; ABDI ESMAT; Yazdanbod Abdas

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Journal: GOVARESH JOURNAL Year:2018 | Volume:23 | Issue:3 Page(s): 146-151

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Title

Multiple Repeats of Helicobacter pylori CagA C-Terminal Motifs Predict the Risk of Gastric Cancer in Iran

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Keywords

H.pyloriQ3

cagAQ3

EPIYAQ2

Gastric cancerQ2

IranQ2

Abstract

Background: cagA, a 120-to 145-kD Helicobacter pylori (H. pylori) protein, increases the risk of atrophic gastritis and Gastric cancer (GC). The pathogenic cagA contains a highly polymorphic Glu-Pro-Ile-Tyr-Ala (EPIYA) repeat region in the C-terminal portion of the protein. The aim of this study was to determine the number and type of EPIYA (glutamine– proline– isoleucine– tyrosine– alanine) motifs within the cagA 3' variable region among H. pylori isolates and their association with GC. Materials and Methods: The total number of 206 individuals (170 controls and 36 patients with GC) referring to the endoscopy units of several cities in Iran (2008-2014) were recruited. The polymerase chain reaction (PCR) amplification was performed to determine the presence of H. pylori, cagA gene, and EPIYA motifs. Results: In this study, 81 (47. 6%) and 22 (61. 1%) of the controls and patients with GC were carriers of cagA+ strains, respectively. The overall frequency of EPIYA-AB, EPIYA-ABC, EPIYA-ABCC, and EPIYA-ABCCC in patients with GC were 0%, 59%, 9%, and 31. 8%, respectively. The results of regression analysis showed a significant association between EPIYA-ABCCC motif and the risk of GC [OR = 9. 99 (95%CI: 2. 17-45. 88), p = 0. 003]. Conclusion: We propose that patients infected with H. pylori strains harboring more than one cagA EPIYA C motif (EPIYA-ABCCC) have an increased risk of GC, thus, testing for this genotype may have clinical usefulness.

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References

Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks: A meta-analysis

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APA: Copy

Sarrami, Somaye, LATIFI NAVID, SAEID, ZAHRI, SABER, ABDI, ESMAT, & Yazdanbod, Abdas. (2018). Multiple Repeats of Helicobacter pylori CagA C-Terminal Motifs Predict the Risk of Gastric Cancer in Iran. GOVARESH JOURNAL, 23(3 ), 146-151. SID. https://sid.ir/paper/86315/en

Vancouver: Copy

Sarrami Somaye, LATIFI NAVID SAEID, ZAHRI SABER, ABDI ESMAT, Yazdanbod Abdas. Multiple Repeats of Helicobacter pylori CagA C-Terminal Motifs Predict the Risk of Gastric Cancer in Iran. GOVARESH JOURNAL[Internet]. 2018;23(3 ):146-151. Available from: https://sid.ir/paper/86315/en

IEEE: Copy

Somaye Sarrami, SAEID LATIFI NAVID, SABER ZAHRI, ESMAT ABDI, and Abdas Yazdanbod, “Multiple Repeats of Helicobacter pylori CagA C-Terminal Motifs Predict the Risk of Gastric Cancer in Iran,” GOVARESH JOURNAL, vol. 23, no. 3 , pp. 146–151, 2018, [Online]. Available: https://sid.ir/paper/86315/en

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