Tumor Suppression or Oncogenic Role of miR-100 in Cancer; Implications for Esophageal Cancer

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Nariman Saleh Fam Lida; BASTAMI MILAD; YAZDANBOD ABBAS

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Journal: GOVARESH JOURNAL Year:2018 | Volume:23 | Issue:3 Page(s): 129-140

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Information Journal Paper

Title

Tumor Suppression or Oncogenic Role of miR-100 in Cancer; Implications for Esophageal Cancer

Author(s)

Nariman Saleh Fam Lida | BASTAMI MILAD | YAZDANBOD ABBAS | Issue Writer Certificate

Keywords

miR-100Q1

cancerQ2

esophagusQ2

miRNAQ1

Abstract

Esophageal cancer (EC) is one of the deadliest malignancies worldwide. Esophageal squamous cell carcinoma (ESCC) constitutes the most common type of EC in Asian countries. Despite advanced surgical techniques, 5-year survival of the affected patients is very low. Therefore, identification of genetic factors and cellular regulatory pathways, including microRNAs (miRNAs), in esophageal carcinogenesis is necessary for early detection. miRNAs are a class of small non-coding RNA about 18-24 nucleotides in length that negatively regulate gene expression. Deregulation of miRNAs was shown to have a crucial role in the pathways underlying tumorigenesis and tumor progression. Evidence indicates that aberrant expression pattern of miR-100 is associated with pathogenesis of ESCC. The function and expression pattern of miR-100 in ESCC are controversial and its effects in tumor progression has not been fully elucidated. A better understanding of molecular procedures mediated by miR-100 in carcinogenesis, may lead to the opportunity of exploring potential miR-100 based therapeutic applications. In this review, we provide an overview of miR-100, including its important regulation pathways and target genes involved in the development of cancers, emphasizing on its potential role in ESCC.

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APA: Copy

Nariman Saleh Fam, Lida, BASTAMI, MILAD, & YAZDANBOD, ABBAS. (2018). Tumor Suppression or Oncogenic Role of miR-100 in Cancer; Implications for Esophageal Cancer. GOVARESH JOURNAL, 23(3 ), 129-140. SID. https://sid.ir/paper/86316/en

Vancouver: Copy

Nariman Saleh Fam Lida, BASTAMI MILAD, YAZDANBOD ABBAS. Tumor Suppression or Oncogenic Role of miR-100 in Cancer; Implications for Esophageal Cancer. GOVARESH JOURNAL[Internet]. 2018;23(3 ):129-140. Available from: https://sid.ir/paper/86316/en

IEEE: Copy

Lida Nariman Saleh Fam, MILAD BASTAMI, and ABBAS YAZDANBOD, “Tumor Suppression or Oncogenic Role of miR-100 in Cancer; Implications for Esophageal Cancer,” GOVARESH JOURNAL, vol. 23, no. 3 , pp. 129–140, 2018, [Online]. Available: https://sid.ir/paper/86316/en

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