Evaluation of acute toxicity of Fe2NiO4 nanoparticle on biochemical parameters in rat liver

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GOLMOHAMMADI R.; HOOSHMANDI Z.; SETORKI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Journal: Journal of Ilam University of Medical Sciences Year:2018 | Volume:26 | Issue:3 Page(s): 134-142

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Title

Evaluation of acute toxicity of Fe2NiO4 nanoparticle on biochemical parameters in rat liver

Author(s)

GOLMOHAMMADI R. | HOOSHMANDI Z. | SETORKI M. | Issue Writer Certificate

Keywords

Fe2Nio4Q1

TransferrinQ1

AlbuminQ1

Lactate dehydrogenaseQ1

Alkaline phosphataseQ1

Abstract

Magnetic nanoparticles composed of iron and nickel have broad application in biological and medical sciences. Increased production and application of nanoparticles has raised concern about their negative side effects on human health. In the present study, we examined the toxicity of Fe2Nio4 nanoparticle on some biochemical parameters of rat’ s liver. In this experimental study, 24 male rats were divided into three groups, including the group receiving Fe2Nio4 nanoparticles at a concentratios of 100 ppm, a group receiving the nanoparticle at a concentration of 200 ppm, and the control group. Then, 2, 7, and 14 days after the intervention, we drew blood samples from the rats and the levels of liver biochemical parameters were determined. According to the results, during the exposure period, serum Albumin level was not significantly different between the groups. In the nanoparticle-treated rats, serum Transferrin level showed a significant increase on the seventh day and a significant decline on the 14th day (P<0. 05). Exposure of rats to the nanoparticle at the doses of 100 and 200 significantly reduced Lactate dehydrogenase level compared to the control group (P<0. 05). Alkaline phosphatase levels in the groups exposed to nanoparticles were not significantly different from that in the control group.

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APA: Copy

GOLMOHAMMADI, R., HOOSHMANDI, Z., & SETORKI, M.. (2018). Evaluation of acute toxicity of Fe2NiO4 nanoparticle on biochemical parameters in rat liver. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(3 ), 134-142. SID. https://sid.ir/paper/89772/en

Vancouver: Copy

GOLMOHAMMADI R., HOOSHMANDI Z., SETORKI M.. Evaluation of acute toxicity of Fe2NiO4 nanoparticle on biochemical parameters in rat liver. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(3 ):134-142. Available from: https://sid.ir/paper/89772/en

IEEE: Copy

R. GOLMOHAMMADI, Z. HOOSHMANDI, and M. SETORKI, “Evaluation of acute toxicity of Fe2NiO4 nanoparticle on biochemical parameters in rat liver,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 3 , pp. 134–142, 2018, [Online]. Available: https://sid.ir/paper/89772/en

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