THE HISTOPATHOLOGIC EFFECTS OF SULFUR DIOXIDE IN MOUSE LIVER FOLLOWING THE CHRONIC AND ACUTE EXPOSURE

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BORHANI N.; RAJAEI F.; JAFARI HOSSEIN

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2007 | Volume:15 | Issue:3 Page(s): 41-48

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Title

THE HISTOPATHOLOGIC EFFECTS OF SULFUR DIOXIDE IN MOUSE LIVER FOLLOWING THE CHRONIC AND ACUTE EXPOSURE

Author(s)

BORHANI N. | RAJAEI F. | JAFARI HOSSEIN | Issue Writer Certificate

Keywords

SULFUR DIOXIDEQ3

MOUSEQ2

LIVERQ3

HISTO-PATHOLOGYQ3

Abstract

Introduction: SULFUR DIOXIDE (SO2) is a dangerous and poisonous gas of pollutant air in industrial countries. It is used to produce sulfuric acid and other industrial substances. Since many people are exposed to this gas daily, in this study, we examined the histopathologic effects of gas on the MOUSE LIVER in both acute and chronic exposures.Materials and Methods: 28 male mice were divided into 4 groups. Group1 (G1) as the control one (not exposed to gas), group2 (G2) which were exposed to high doses of SULFUR DIOXIDE (100ppm) and group3 (G3) & group4 (G4) which were exposed to a low dose of SULFUR DIOXIDE for 5 minutes for 1 to 3 weeks (20ppm). Finally, the mice were slaughtered. First, the LIVERs were assessed macroscopically and then a biopsy on the LIVERs was assessed microscopically. At last the data were analyzed statistically.Findings: The results show that the mean number of Kupffer cells in G2, G3, and G4 significantly increased compared with the control group (9±1.0, 10±10, 11±1.2 vs 7 7±1.4 p<0.0001). Qualitative observations also show a significantly increase in the rate of LIVER cells necrosis and deformation of hepatic cords and sinusoids with an increase of inflammatory reactions in the experimental mice.Conclusion: The present study indicated that the LIVER can be damaged by the chronic and acute exposure to SULFUR DIOXIDE.

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APA: Copy

BORHANI, N., RAJAEI, F., & JAFARI, HOSSEIN. (2007). THE HISTOPATHOLOGIC EFFECTS OF SULFUR DIOXIDE IN MOUSE LIVER FOLLOWING THE CHRONIC AND ACUTE EXPOSURE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 15(3), 41-48. SID. https://sid.ir/paper/89787/en

Vancouver: Copy

BORHANI N., RAJAEI F., JAFARI HOSSEIN. THE HISTOPATHOLOGIC EFFECTS OF SULFUR DIOXIDE IN MOUSE LIVER FOLLOWING THE CHRONIC AND ACUTE EXPOSURE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;15(3):41-48. Available from: https://sid.ir/paper/89787/en

IEEE: Copy

N. BORHANI, F. RAJAEI, and HOSSEIN JAFARI, “THE HISTOPATHOLOGIC EFFECTS OF SULFUR DIOXIDE IN MOUSE LIVER FOLLOWING THE CHRONIC AND ACUTE EXPOSURE,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 3, pp. 41–48, 2007, [Online]. Available: https://sid.ir/paper/89787/en

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