THE ASSOCIATION BETWEEN TELOMERES, TELOMERASE, CANCER AND AGING

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HAMIDI M.; AHMADI N.A.; BASTAMI NEZHAD S.

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Journal: Journal of Ilam University of Medical Sciences Year:2013 | Volume:21 | Issue:1 Page(s): 89-96

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Information Journal Paper

Title

THE ASSOCIATION BETWEEN TELOMERES, TELOMERASE, CANCER AND AGING

Author(s)

HAMIDI M. | AHMADI N.A. | BASTAMI NEZHAD S. | Issue Writer Certificate

Keywords

TELOMERESQ2

TELOMERASEQ2

CANCERQ2

AGINGQ1

Abstract

Telomere is physically terminal of linear chromosomes composed of a non-coding sequence. Mammalian TELOMERES consist of a variable number of repeated sequences (TTAAGGG) that is added by TELOMERASE to the 3' end of chromosomes. TELOMERES protect chromosomes from degradation, chromosome attachment to chromosomes and prevent other forms of defective recombination. Despite the contradictory role of TELOMERASE dysfunction in specific genetic diseases, association between telomere dysfunction with AGING is now open for discussion. The most common way for CANCER cells to achieve their specific development into tumor formation is probably through terlomerase activation. Clarify the complexities of controlling TELOMERASE may provide a route to target TELOMERASE activity as a routine method of treatment for many patients with CANCER and be considered as a target for therapeutics. In this paper, we have a brief look at the structure and function of telomere and TELOMERASE and then the link between TELOMERASE activity in AGING and CANCER, and the relationship between different aspects have been investigated in detail. In addition the other roles of TELOMERASE in the body are discussed. Finally, the use of TELOMERASE as a drug target in CANCER therapy has been considered.

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APA: Copy

HAMIDI, M., AHMADI, N.A., & BASTAMI NEZHAD, S.. (2013). THE ASSOCIATION BETWEEN TELOMERES, TELOMERASE, CANCER AND AGING. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 21(1), 89-96. SID. https://sid.ir/paper/89835/en

Vancouver: Copy

HAMIDI M., AHMADI N.A., BASTAMI NEZHAD S.. THE ASSOCIATION BETWEEN TELOMERES, TELOMERASE, CANCER AND AGING. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;21(1):89-96. Available from: https://sid.ir/paper/89835/en

IEEE: Copy

M. HAMIDI, N.A. AHMADI, and S. BASTAMI NEZHAD, “THE ASSOCIATION BETWEEN TELOMERES, TELOMERASE, CANCER AND AGING,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 1, pp. 89–96, 2013, [Online]. Available: https://sid.ir/paper/89835/en

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