Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta

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SAFAVI E.; HOMAYOUNI TABRIZI M.; KARIMI E.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Ilam University of Medical Sciences Year:2018 | Volume:26 | Issue:2 Page(s): 45-56

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Title

Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta

Author(s)

SAFAVI E. | HOMAYOUNI TABRIZI M. | KARIMI E. | Issue Writer Certificate

Keywords

AngiogenesisQ1

ZnOQ1

Chorioallantoic membraneQ1

Abstract

Introduction: Angiogenesis is a dynamic procedure that plays a key role in physiological and pathological conditions such as tumor growth. Today, the green synthesized nanoparticles are applied for cancer treatment due to their anti-angiogenic properties. In the green method, the plant extract is used for metal ions exchange into a nanoparticle as an economic and environmental-friendly procedure. In the present study, the anti-angiogenic effects of green ZnO nanoparticles synthesized by Persicaria bistorta root extract were evaluated. Materials & Methods: As to investigate the anti-angiogenic effects of green synthesized ZnO nanoparticles, 30 Ross eggs were randomly divided into 6 groups including the control, laboratory control, and 4 experimental groups treated by 250, 500, 1000, and 2000 μ g/ml ZnO nanoparticles. On the day 12 after incubation, the effects of ZnO were assessed. The obtained data was analyzed using the SPSS software and ANOVA statistical test. The P<0. 05 was regarded as a significance. Findings: The obtained data showed that the 1000 and 2000 μ g/ml of green synthesized ZnO nanoparticles significantly decreased the number and length of Chorioallantoic membrane vascular splits (P<0. 001), weight and size and the head to tail length of the chicken’ s embryos in comparison to the normal controls (P<0. 05). Discussion & Conclusion: Our results demonstrated that the green ZnO nanoparticles synthesized by aqueous Persicaria bistorta root extract restricted the Angiogenesis.

Cites

Evaluation of (cytotoxicity and angiogenesis) of Zinc oxide nanoparticles Synthesized by aqueous extract of Origanum majorana

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APA: Copy

SAFAVI, E., HOMAYOUNI TABRIZI, M., & KARIMI, E.. (2018). Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(2 ), 45-56. SID. https://sid.ir/paper/89971/en

Vancouver: Copy

SAFAVI E., HOMAYOUNI TABRIZI M., KARIMI E.. Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(2 ):45-56. Available from: https://sid.ir/paper/89971/en

IEEE: Copy

E. SAFAVI, M. HOMAYOUNI TABRIZI, and E. KARIMI, “Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 2 , pp. 45–56, 2018, [Online]. Available: https://sid.ir/paper/89971/en

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