BREAST CANCER AND GLUTATHIONE S-TRANSFERASE GENETIC POLYMORPHISM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AZIZIAN M.; YAGHMAEI B.; KHOSRAVI AFRA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2009 | Volume:17 | Issue:1 Page(s): 31-38

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

2,324

Download:

Cites:

Information Journal Paper

Title

BREAST CANCER AND GLUTATHIONE S-TRANSFERASE GENETIC POLYMORPHISM

Author(s)

AZIZIAN M. | YAGHMAEI B. | KHOSRAVI AFRA | Issue Writer Certificate

Keywords

BREAST CANCERQ2

GLUTATHIONE S-TRANSFERASEQ3

POLYMORPHISMQ1

Abstract

Introduction: BREAST CANCER is one of the most common known cancers among women of all the racial groups. Thus, a study on both the genetic and environmental factors provides a new chance for us to comprehend the risks of BREAST CANCER. Molecular studies were performed in order to elucidate the relationship between three polymorphic metabolic enzymes with BREAST CANCER.Materials & Methods: In this case-control study, the POLYMORPHISMs of GLUTATHIONE S-TRANSFERASE (GST) M1, T1 and P1 were analyzed by PCR in genomic DNA from blood samples of 31 female BREAST CANCER patients against 46 women as the control group. To investigate any possible relationships between genotype in GSTT1 and GSTM 1 a Mult. PCR method was used, while for genotype in GSTP 1 a PCR-RFLP method was designed and followed. To determine the relationship between genotypes of GSTT1, GSTM1, and GSTP1 with breast-canser risks, the OR (odd ratio) was calculated with a 95 certainty distance.Findings: GSTT1 null genotype was a risk factor (odd ratio (OR), 4.75, 95% confidence interval (CI), 1.66-13.51). Hetrozygoute POLYMORPHISM of GSTP1 at nucleotide 313 was associated (OR, 3.85; 95% CI, 1.39- 10.61). GSTM1 null genotype was not associated with the BREAST CANCER risk.Discussion & Conclusion: According to the achievements of the study, we conclude that GSTP1 and GSTT1 genes could play a role in carcinogenesis in the BREAST CANCER.

Cites

No record.

References

No record.

Cite

APA: Copy

AZIZIAN, M., YAGHMAEI, B., & KHOSRAVI, AFRA. (2009). BREAST CANCER AND GLUTATHIONE S-TRANSFERASE GENETIC POLYMORPHISM. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 17(1), 31-38. SID. https://sid.ir/paper/89983/en

Vancouver: Copy

AZIZIAN M., YAGHMAEI B., KHOSRAVI AFRA. BREAST CANCER AND GLUTATHIONE S-TRANSFERASE GENETIC POLYMORPHISM. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;17(1):31-38. Available from: https://sid.ir/paper/89983/en

IEEE: Copy

M. AZIZIAN, B. YAGHMAEI, and AFRA KHOSRAVI, “BREAST CANCER AND GLUTATHIONE S-TRANSFERASE GENETIC POLYMORPHISM,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 1, pp. 31–38, 2009, [Online]. Available: https://sid.ir/paper/89983/en

Related Journal Papers