THE MICROSCOPIC AND ULTRA STRUCTURAL STUDY OF TESTICULAR TISSUE FOLLOWING TIME DEPENDENT ADMINISTRATION OF METHYLPHENIDATE IN ADULT RATS

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MOUSAVIPOUR GOHAR Z.; KIANIFARD D.; KHALILZADEH E.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:24 | Issue:4 Page(s): 83-94

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Title

THE MICROSCOPIC AND ULTRA STRUCTURAL STUDY OF TESTICULAR TISSUE FOLLOWING TIME DEPENDENT ADMINISTRATION OF METHYLPHENIDATE IN ADULT RATS

Author(s)

MOUSAVIPOUR GOHAR Z. | KIANIFARD D. | KHALILZADEH E. | Issue Writer Certificate

Keywords

METHYLPHENIDATEQ2

RATQ1

TESTICULAR TISSUEQ1

ULTRASTRUCTUREQ1

Abstract

Introduction: TESTICULAR TISSUE is susceptible to environmental risk factors. Structural and functional alterations in spermatogenesisare the most important factors involved infertility complications. METHYLPHENIDATE is amphetamine derivatives. This drug can approve for treatment of attention deficit/hyperactivity disorder (ADHD), tachycardia syndrome, narcolepsy, depression. There is a little data about the effects of METHYLPHENIDATE on test iculartissue. In this study, time dependent effects of METHYLPHENIDATE were evaluated ontesticular tissue in microscopic and ultrastructural levels.Materials & methods: 30 adult Wistar RATswere divided into three groups as control, short-term METHYLPHENIDATE (10 mg/kg/day)treated for two weeks and long-term METHYLPHENIDATE (10 mg/kg/day) treated for eight weeks. Histomorphological and ultrastructural assessments were prepared on TESTICULAR TISSUE through routine histologic and electron microscopic methods.Findings: Some alterations such as tubular atrophy and transformation and disarrangement of sper matogenic cells were observed in TESTICULAR TISSUE following time dependent administration of METHYLPHENIDATE. Deformation of mitochondria, increment of collagen fibers and basement membrane thickness, were the main cellular and structural alterationsobserved in ultrastructural level.Discussion & conclusions: The results of this study indicated that the process of spermatogenesis reduces temporary following short term administration of METHYLPHENIDATE; however, it seems that repeated administration of METHYLPHENIDATE progressively leads to some degrees of tissue habitation and resistance.

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APA: Copy

MOUSAVIPOUR GOHAR, Z., KIANIFARD, D., & KHALILZADEH, E.. (2016). THE MICROSCOPIC AND ULTRA STRUCTURAL STUDY OF TESTICULAR TISSUE FOLLOWING TIME DEPENDENT ADMINISTRATION OF METHYLPHENIDATE IN ADULT RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 24(4), 83-94. SID. https://sid.ir/paper/90164/en

Vancouver: Copy

MOUSAVIPOUR GOHAR Z., KIANIFARD D., KHALILZADEH E.. THE MICROSCOPIC AND ULTRA STRUCTURAL STUDY OF TESTICULAR TISSUE FOLLOWING TIME DEPENDENT ADMINISTRATION OF METHYLPHENIDATE IN ADULT RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(4):83-94. Available from: https://sid.ir/paper/90164/en

IEEE: Copy

Z. MOUSAVIPOUR GOHAR, D. KIANIFARD, and E. KHALILZADEH, “THE MICROSCOPIC AND ULTRA STRUCTURAL STUDY OF TESTICULAR TISSUE FOLLOWING TIME DEPENDENT ADMINISTRATION OF METHYLPHENIDATE IN ADULT RATS,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 4, pp. 83–94, 2016, [Online]. Available: https://sid.ir/paper/90164/en

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