Plasma Changes of some Biomarkers and Adenosine Deaminase Activity in Streptozotocin-Induced Diabetes Mellitus in Rats Following Administration of Different doses of Pure Extract of Cynodon dactylon Rhizome

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Digaleh F.; AZIMZADEH K.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Ilam University of Medical Sciences Year:2018 | Volume:26 | Issue:4 Page(s): 126-135

Download Full-Text

Persian Verion

View:

346

Download:

Cites:

Information Journal Paper

Title

Plasma Changes of some Biomarkers and Adenosine Deaminase Activity in Streptozotocin-Induced Diabetes Mellitus in Rats Following Administration of Different doses of Pure Extract of Cynodon dactylon Rhizome

Author(s)

Digaleh F. | AZIMZADEH K. | Issue Writer Certificate

Keywords

Cynodon dactylonQ1

Cardiovascular biomarkersQ1

Inflammatory markersQ1

Diabetes mellitusQ1

Abstract

Introduction: The aim of this study was to evaluate the changes of some biomarkers in streptozotocin-induced diabetic rats following the administration of pure extract of Cynodon dactylon. Materials & Methods: In this study, after dividing 50 rats into five groups and induction of Diabetes mellitus in four groups, pure extract of Cynodon dactylon was administered at 150, 300, and 450 mg/kg/day concentrations to three diabetic groups for three months. The positive control group (diabetic group without Cynodon dactylon administarion) along with negative control group (non-diabetic group) did not receive any extract. Afterwards, some biomarkers along with plasma adenosine deaminase (ADA) activity were assessed in all the groups. Findings: The results showed a significant increase in all the Inflammatory markers, including ADA Hcy, and cTnI (P≤ 0. 01) and a significant reduction in marker of tissue damage, gelsolin (GLS), (P≤ 0. 01) in the positive control group compared with the control group. We also found a significant decrease in these parameters (P≤ 0. 01) and a significant increase in marker of tissue damage (GLS) following the administration of 450 mg/kg of the extract compared to the positive control and negative control groups. Discussion & Conclusions: It can be concluded that the extract of Cynodon dactylon, especially at the concentration of 450 mg/kg of body weight, can significantly reduce cardiovascular and inflammatory biomarkers and elevate GLS concentration in diabetic rats.

Cites

No record.

References

No record.

Cite

APA: Copy

Digaleh, F., & AZIMZADEH, K.. (2018). Plasma Changes of some Biomarkers and Adenosine Deaminase Activity in Streptozotocin-Induced Diabetes Mellitus in Rats Following Administration of Different doses of Pure Extract of Cynodon dactylon Rhizome. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(4 ), 126-135. SID. https://sid.ir/paper/90215/en

Vancouver: Copy

Digaleh F., AZIMZADEH K.. Plasma Changes of some Biomarkers and Adenosine Deaminase Activity in Streptozotocin-Induced Diabetes Mellitus in Rats Following Administration of Different doses of Pure Extract of Cynodon dactylon Rhizome. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(4 ):126-135. Available from: https://sid.ir/paper/90215/en

IEEE: Copy

F. Digaleh, and K. AZIMZADEH, “Plasma Changes of some Biomarkers and Adenosine Deaminase Activity in Streptozotocin-Induced Diabetes Mellitus in Rats Following Administration of Different doses of Pure Extract of Cynodon dactylon Rhizome,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 4 , pp. 126–135, 2018, [Online]. Available: https://sid.ir/paper/90215/en

Related Journal Papers