EFFECT OF ZINC OXIDE NANOPARTICLES ON THE PIGMENT PRODUCTION OF CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA

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NAKHAEI MOGHADDAM M.; NAJAFI M.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:24 | Issue:6 Page(s): 107-116

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Title

EFFECT OF ZINC OXIDE NANOPARTICLES ON THE PIGMENT PRODUCTION OF CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA

Author(s)

NAKHAEI MOGHADDAM M. | NAJAFI M. | Issue Writer Certificate

Keywords

PYOCYANINQ1

NANOPARTICLESQ1

ZINC OXIDEQ1

PSEUDOMONAS AERUGINOSAQ2

Abstract

Introduction: NANOPARTICLES with the different sizes, surfaces and chemical characteristics can have different applications. PSEUDOMONAS AERUGINOSA is an opportunistic bacterium that has the ability to produce pigment. The aim of this study was to investigate the effect of ZINC OXIDE (ZnO) NANOPARTICLES on pigment production of clinical isolates of PSEUDOMONAS AERUGINOSA.Materials & methods: In this description cross-sectional study, 15 clinical isolates of PSEUDOMONAS AERUGINOSA were collected from hospitals in Mashhad. Bacteria were identified using biochemical tests and polymerase chain reaction (PCR) by specific primers of exoA gene. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of ZINC OXIDE NANOPARTICLES (diameter of 4-7 nm) were determined by agar dilution method. Glycerol- alanine (GA) medium containing different concentrations (0, 20, 40 and 60 mg/ml) of NANOPARTICLES were used for investigation of the effect of ZnO NANOPARTICLES on pigment production. The pigment was extracted by adding chloroform.Findings: All clinical isolates were identified by biochemical experiments as P. aeruginosa and exoA gene was detected in all bacteria. The average MIC and MBC of ZnO NANOPARTICLES were 60 mg/ml and 70 mg/ml, respectively. All isolates were examined and compared for PYOCYANIN pigment production. The pigment production was significantly reduced with increasing concentrations the ZnO NANOPARTICLES (p<0.05).Discussion & Conclusion: ZINC OXIDE NANOPARTICLES had inhibitory effect on bacteria and pigment production. Pigment production decreased with increasing concentrations of NANOPARTICLES. ZnO NANOPARTICLES could be used in prevention or helping to treat P. aeruginosa infections.

Cites

The investigation of the effect of the interaction of zinc oxide nanoparticles with the DNA of the thymus gland

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APA: Copy

NAKHAEI MOGHADDAM, M., & NAJAFI, M.. (2017). EFFECT OF ZINC OXIDE NANOPARTICLES ON THE PIGMENT PRODUCTION OF CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 24(6), 107-116. SID. https://sid.ir/paper/90348/en

Vancouver: Copy

NAKHAEI MOGHADDAM M., NAJAFI M.. EFFECT OF ZINC OXIDE NANOPARTICLES ON THE PIGMENT PRODUCTION OF CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;24(6):107-116. Available from: https://sid.ir/paper/90348/en

IEEE: Copy

M. NAKHAEI MOGHADDAM, and M. NAJAFI, “EFFECT OF ZINC OXIDE NANOPARTICLES ON THE PIGMENT PRODUCTION OF CLINICAL ISOLATES OF PSEUDOMONAS AERUGINOSA,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 6, pp. 107–116, 2017, [Online]. Available: https://sid.ir/paper/90348/en

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