SIMVASTATIN REINFORCES PROTECTIVE MECHANISM OF ATRIOVENTRICULAR NODE DURING EXPERIMENTAL MODEL OF ATRIAL FIBRILLATION (AF) IN RABBIT

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NAYEBPOUR M.; KHOURI V.; POURABOUK M.; BODAGHABADI FAKHRI

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Seminar Paper

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Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

SIMVASTATIN REINFORCES PROTECTIVE MECHANISM OF ATRIOVENTRICULAR NODE DURING EXPERIMENTAL MODEL OF ATRIAL FIBRILLATION (AF) IN RABBIT

Author(s)

NAYEBPOUR M. | KHOURI V. | POURABOUK M. | BODAGHABADI FAKHRI

Keywords

SIMVASTATIN

ATRIOVENTRICULAR NODE

ATRIAL FIBRILLATION

Abstract

Statins show direct anti-arrhythmic effects through potentially many different mechanisms. Several recent studies have shown the modulatory effects of statins on ionic channels in the atria and ventricular tissue. In the present study, we tested the hypothesis of protective acute effects of simvastatin on electrophysiological properties of atrioventricular node in an experimental model of AF in rabbit. Protective nodal properties were characterized by stimulation protocols in one groups of (N=7) isolated perfused AV-Node of rabbits. To quantify the effects of simvastatin on the AV node, AF was simulated by random high atrial pacing. The stimulation protocols were carried out during control conditions (no intervention) and in the presence of various concentrations of simvastatin. Results showed that simvastatin in a concentration–dependent manner (0.5-10μM) prolonged nodal conduction time, refractory period and Wenckebach. We observed a significant increase in the average H–H intervals and numbers of concealed beats by selective high concentrations of simvastatin. Zone of concealment was widened by this drug in the high concentration. In Conclusion, higher-concentrations of simvastatin have the greatest protective effect on AV-Node. These effects may imply the potential role of simvastatin at the therapeutic concentrations for treatment of AVNRT.

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APA: Copy

NAYEBPOUR, M., KHOURI, V., POURABOUK, M., & BODAGHABADI, FAKHRI. (2009). SIMVASTATIN REINFORCES PROTECTIVE MECHANISM OF ATRIOVENTRICULAR NODE DURING EXPERIMENTAL MODEL OF ATRIAL FIBRILLATION (AF) IN RABBIT. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903581/en

Vancouver: Copy

NAYEBPOUR M., KHOURI V., POURABOUK M., BODAGHABADI FAKHRI. SIMVASTATIN REINFORCES PROTECTIVE MECHANISM OF ATRIOVENTRICULAR NODE DURING EXPERIMENTAL MODEL OF ATRIAL FIBRILLATION (AF) IN RABBIT. 2009. Available from: https://sid.ir/paper/903581/en

IEEE: Copy

M. NAYEBPOUR, V. KHOURI, M. POURABOUK, and FAKHRI BODAGHABADI, “SIMVASTATIN REINFORCES PROTECTIVE MECHANISM OF ATRIOVENTRICULAR NODE DURING EXPERIMENTAL MODEL OF ATRIAL FIBRILLATION (AF) IN RABBIT,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903581/en

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