EVALUATION OF ANTIMICROBIAL EFFECTS OF NOVEL TRIAZOLE AND OXADIAZOL DERIVATIVES

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MEHREGAN HADI; TABATABAEI S.A.; SHAFIZADEH S.

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

EVALUATION OF ANTIMICROBIAL EFFECTS OF NOVEL TRIAZOLE AND OXADIAZOL DERIVATIVES

Author(s)

MEHREGAN HADI | TABATABAEI S.A. | SHAFIZADEH S.

Keywords

OXADIAZOLE

TRIAZOLE

ANTIMICROBIAL ACTIVITY

METHYCILLINRESISTANT STAPHYLOCOCCUS AUREUS

VANCOMYCIN-RESISTANT ENTEROCOCCUS FAECALIS

Abstract

Oxadiazole derivatives have a broad range of biological activities including antimicrobial, anti-inflammatory and antiparasite, and triazoles possess antifungal activity. Antimicrobial activity of a group of novel oxadiazole and triazole derivatives was thus investigated in this stage. A few novel oxadiazole and triazole derivatives previously synthesized in our school were dissolved in DMSO at 2 mg/ml and tested against an array of 9 Gram-positive (GPB) and Gram-negative (GNB) bacteria as well as 2 fungi (Candida albicans and Aspergillus niger) by the cup-plate method. All testcompounds could produce distinct clear zones against most of GPBs.However, only compounds 6, 7 and 8 had a significant inhibitory effect on GNBs. Compound 9 was active against methicillin-resistant Staphylococcus aureus (MRSA), and 8 against vancomycin-resistant Enterococcus faecalis (VRE). MIC values determined against MRSA for compounds 3 and 4 were 5.26 and 12.5 μg/ml, respectively. Furthermore, none of the compounds showed activity against fungi. These compounds showed a good antibacterial effect against GPBs and appeared to be good candidates for further studies in order to find new key structures against troublesome bacteria like MRSA and VRE.

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APA: Copy

MEHREGAN, HADI, TABATABAEI, S.A., & SHAFIZADEH, S.. (2009). EVALUATION OF ANTIMICROBIAL EFFECTS OF NOVEL TRIAZOLE AND OXADIAZOL DERIVATIVES. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903868/en

Vancouver: Copy

MEHREGAN HADI, TABATABAEI S.A., SHAFIZADEH S.. EVALUATION OF ANTIMICROBIAL EFFECTS OF NOVEL TRIAZOLE AND OXADIAZOL DERIVATIVES. 2009. Available from: https://sid.ir/paper/903868/en

IEEE: Copy

HADI MEHREGAN, S.A. TABATABAEI, and S. SHAFIZADEH, “EVALUATION OF ANTIMICROBIAL EFFECTS OF NOVEL TRIAZOLE AND OXADIAZOL DERIVATIVES,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903868/en

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