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Title

THE EFFECT OF AMARANTHUS CAUDATUS HYDROALCOHOLIC EXTRACT ON ATHEROSCLEROSIS IN RABBIT

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Abstract

 OBJECTIVES: Cardiovascular and atherosclerosis that is caused by a gradual deposition of lipids in muscular arteries remain a major cause of mortality word wide. In this study the effect of Amaranthus caudatus hydroalcoholic extract on atherosclerosis was investigated in rabbit.METHOD: 20 male rabbits were randomaly distributed in to four groups of five each. Animals in group 1 received regular rabbit chow, in group 2 received HCD, in group 3 received Amaranthus hydroalcoholic extract and in group 4 received HCD and Amaranthus hydroalcoholic extract (150mg/kg wb) respectively for 60 days. In the beginning and final stage of the experimental period, blood samples were taken to measurement concentration of cholesterol, TG, HDL, LDL and AI. The aorta was removed for assessment of atherosclerotic plaques.RESULTS: The results indicate that extract increase significantly (P<0.05) the level of HDL and reduce significantly (P<0.05) the levels of TC, TG, LDL, OX-LDL, hs-CRP and AI in group compared with group hypercholesterol. Severity of aortic atherosclerosis and degree of atherosclerotic plaque in groups that treatment with extract reduce significantly (P<0.05) compared with group2.CONCLUSION: The reduction of atherognic lipoproteins by Amaranthus caudatus hydroalcoholic extract can be due to the antioxidant effect of this extract.

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    APA: Copy

    KABIRI, NAJMEH, MADANI, H., ASGARI, S., MAHZOUNI, P., & EBRAHIMIPOUR, H.. (2007). THE EFFECT OF AMARANTHUS CAUDATUS HYDROALCOHOLIC EXTRACT ON ATHEROSCLEROSIS IN RABBIT. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904686/en

    Vancouver: Copy

    KABIRI NAJMEH, MADANI H., ASGARI S., MAHZOUNI P., EBRAHIMIPOUR H.. THE EFFECT OF AMARANTHUS CAUDATUS HYDROALCOHOLIC EXTRACT ON ATHEROSCLEROSIS IN RABBIT. 2007. Available from: https://sid.ir/paper/904686/en

    IEEE: Copy

    NAJMEH KABIRI, H. MADANI, S. ASGARI, P. MAHZOUNI, and H. EBRAHIMIPOUR, “THE EFFECT OF AMARANTHUS CAUDATUS HYDROALCOHOLIC EXTRACT ON ATHEROSCLEROSIS IN RABBIT,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904686/en

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    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
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