COMPARISON OF METFORMIN AND PIOGLITAZONE ON HS-CRP LEVELS IN PATIENTS WITH TYPE II DIABETES

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ZIAEE A.; HASHEMIPOUR S.; GHAVAM S.; JAVADI A.; GHAVAM R.; BARIKANI A.; ESMAILZADEHHA N.

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Journal: Journal of Ilam University of Medical Sciences Year:2013 | Volume:21 | Issue:2 Page(s): 28-36

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Title

COMPARISON OF METFORMIN AND PIOGLITAZONE ON HS-CRP LEVELS IN PATIENTS WITH TYPE II DIABETES

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Keywords

DIABETES MELLITUSQ2

METFORMINQ2

PIOGLITAZONEQ2

HS-CRPQ2

HBA1CQ2

Abstract

Introduction: Heart disease, particularly coronary heart disease, is a major cause of mortality among patients with DIABETES MELLITUS. High level of (high sensitivity C reactive protein) HS-CRP is considered as a risk factor for heart diseases. Treatment with PIOGLITAZONE and/or METFORMIN decreases the serum concentration of HS-CRP in patients with or without type II diabetes. The purpose of this study was to compare the effects of PIOGLITAZONE and METFORMIN on HS-CRP level in patients with type II diabetes.Materials & Methods: A randomized clinical trial was performed on 40 patients with type 2 diabetes and the defined inclusion criteria. Patients were divided into two groups: receiving METFORMIN and receiving PIOGLITAZONE. Blood levels of cholesterol, triglycerides, fasting blood glucose, alanine transaminase, aspartat transaminase, glycolsylated hemoglobin (HbA1C) and HS-CRP were measured in all subjects before and after 3 month drug therapy. The average change in each group before and after drug therapy was analyzed by paired T-test. Mean changes of the parameters between the groups were compared by independent T-test.Findings: In both groups, HS-CRP level was significantly decreased after drug therapy. The mean change of HS-CRP, HBA1C, and cholesterol was significantly higher in METFORMIN treated group.Discussion & Conclusion: Since the average reduction in the level of HS-CRP, cholesterol and HBA1C in the diabetic patients treated with METFORMIN was significantly higher than those patients treated with PIOGLITAZONE, the treatment with METFORMIN is recommended to reduce the risk of heart disease in patients with type 2 DIABETES MELLITUS.

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APA: Copy

ZIAEE, A., HASHEMIPOUR, S., GHAVAM, S., JAVADI, A., GHAVAM, R., BARIKANI, A., & ESMAILZADEHHA, N.. (2013). COMPARISON OF METFORMIN AND PIOGLITAZONE ON HS-CRP LEVELS IN PATIENTS WITH TYPE II DIABETES. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 21(2), 28-36. SID. https://sid.ir/paper/90493/en

Vancouver: Copy

ZIAEE A., HASHEMIPOUR S., GHAVAM S., JAVADI A., GHAVAM R., BARIKANI A., ESMAILZADEHHA N.. COMPARISON OF METFORMIN AND PIOGLITAZONE ON HS-CRP LEVELS IN PATIENTS WITH TYPE II DIABETES. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;21(2):28-36. Available from: https://sid.ir/paper/90493/en

IEEE: Copy

A. ZIAEE, S. HASHEMIPOUR, S. GHAVAM, A. JAVADI, R. GHAVAM, A. BARIKANI, and N. ESMAILZADEHHA, “COMPARISON OF METFORMIN AND PIOGLITAZONE ON HS-CRP LEVELS IN PATIENTS WITH TYPE II DIABETES,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 2, pp. 28–36, 2013, [Online]. Available: https://sid.ir/paper/90493/en

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