SIMULATION OF BLOOD BRAIN BARRIER USING STATISTICAL METHOD

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YAHAGHI E.; MOVAFEGHI A.; SOLTANIAN ZADEH H.; SHAHRIAREI M.; FATOURAEE N.; GITI -

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Seminar Paper

Paper Information

Seminar: IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING
Year:2004 | Issue:11

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Title

SIMULATION OF BLOOD BRAIN BARRIER USING STATISTICAL METHOD

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Abstract

WE DESCRIBE A NEW METHOD TO SIMULATE CROSSING OF CONTRAST AGENT ACCORDING TO PERMEABILITY AND LESIONS OF BLOOD BRAIN BARRIER. EQUATIONS OF TISSUE HOMOGENEITY MODEL (ADIABATIC EQUATIONS) AND COMPARTMENT MODEL ARE USED FOR DESCRIPTION OF DISTRIBUTION OF CONTRAST AGENT IN CAPILLARY AND EXTRAVASCULAR SPACE. ANALYTICAL METHODS FOR SOLVING ADIABATIC EQUATIONS WITH NON-UNIFORM PERMEABILITY AND REAL ARTERIAL INPUT FUNCTION (AIF) ARE COMPLICATED. WE CONSIDER CROSSING OF CONTRAST AGENT THROUGH THE CAPILLARY AND BBB AS INTRINSICALLY STATISTICAL PROCESSES. THEREFORE, IT IS SIMULATED BY A STOCHASTIC METHOD (MONTE CARLO METHOD). IN OUR MODEL, CAPILLARY IS DIVIDED INTO MULTIPLE SECTIONS AS IN PATLAK MODEL AND CONTRAST AGENT MOVES FROM ONE SECTION TO OTHER SECTIONS. FOR CAPILLARY INPUT, AIF IS USED DIRECTLY FROM REAL DATA. WITHOUT SOLVING ANY EQUATIONS, WE DERIVE THE CONCENTRATION OF CONTRAST AGENT AS A FUNCTION OF TIME AND DISTANCE IN THE CAPILLARY FOR NORMAL (NOT PERMEABLE DUE TO BBB) AND ABNORMAL CAPILLARY WITH UNIFORM AND NON-UNIFORM PERMEABILITY.

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APA: Copy

YAHAGHI, E., MOVAFEGHI, A., SOLTANIAN ZADEH, H., SHAHRIAREI, M., FATOURAEE, N., & GITI, -. (2004). SIMULATION OF BLOOD BRAIN BARRIER USING STATISTICAL METHOD. IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING. SID. https://sid.ir/paper/906397/en

Vancouver: Copy

YAHAGHI E., MOVAFEGHI A., SOLTANIAN ZADEH H., SHAHRIAREI M., FATOURAEE N., GITI -. SIMULATION OF BLOOD BRAIN BARRIER USING STATISTICAL METHOD. 2004. Available from: https://sid.ir/paper/906397/en

IEEE: Copy

E. YAHAGHI, A. MOVAFEGHI, H. SOLTANIAN ZADEH, M. SHAHRIAREI, N. FATOURAEE, and - GITI, “SIMULATION OF BLOOD BRAIN BARRIER USING STATISTICAL METHOD,” presented at the IRANIAN CONFERENCE ON BIOMEDICAL ENGINEERING. 2004, [Online]. Available: https://sid.ir/paper/906397/en

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