SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF ACETAMINOPHEN, IBUPROFEN AND CAFFEINE IN BIOLOGICAL AND DRUG SAMPLES USING WAVELET-OSC-PLS IBUPROFEN

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BERENJIAN BAHAREH; NIAZI ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Seminar Paper

Paper Information

Seminar: IRANIAN CHEMISTRY CONGRESS
Year:2014 | Issue:17

Download Full-Text

View:

166

Download:

Information Seminar Paper

Title

SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF ACETAMINOPHEN, IBUPROFEN AND CAFFEINE IN BIOLOGICAL AND DRUG SAMPLES USING WAVELET-OSC-PLS IBUPROFEN

Author(s)

BERENJIAN BAHAREH | NIAZI ALI | Issue Writer Certificate

Keywords

ACETAMINOPHEN

IBUPROFEN

CAFFEINE

DETERMINATION

WAVELET

OSC

PLS

Abstract

BACKGROUND: A NOVEL AND FAST METHOD FOR SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN, IBUPROFEN AND CAFFEINE IN REAL SAMPLES SUCH AS HUMAN PLASMA AND DRUG SAMPLES WAS DEVELOPED BY USING CHEMOMETRICS METHODS. ALL FACTORS EFFECTING ON THE SENSITIVITY WERE OPTIMIZED. THE SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN, IBUPROFEN AND CAFFEINE MIXTURES BY USING SPECTROPHOTOMETRIC METHOD IS DIFFICULT PROBLEM, DUE TO THE SPECTRAL INTERFERENCES. THE WAVELET ORTHOGONAL SIGNAL CORRECTION WITH PLS (WOSC-PLS) METHOD WAS THEN APPLIED FOR SIMULTANEOUS DETERMINATION OF THESE DRUGS METHODS: STOCK SOLUTIONS OF ACETAMINOPHEN, IBUPROFEN AND CAFFEINE (1000 MG ML-1) WERE PREPARED. A UNIVERSAL BUFFER SOLUTION (PH 7.0) WAS PREPARED DAILY. A HEWLETT-PACKARD 8453 DIODE ARRAY SPECTROPHOTOMETER WAS USED FOR UV-VISIBLE SPECTRA ACQUISITION. ALL COMPUTATIONS FOR THIS WORK WERE PERFORMED IN MATLAB VERSION 8.1 ON A PERSONAL COMPUTER. PLS, OSC, WOSC PROGRAMS WERE OBTAINED USING THE PLS_TOOLBOX VERSION 4.0 FROM EIGENVECTOR RESEARCH INC. ALL DATA WERE MEAN CENTERED BEFORE USE FOR PLS, OSC-PLS AND WOSC-PLS MODELING.RESULTS: UNDER OPTIMIZED CONDITIONS, THE CALIBRATION CURVES WERE LINEAR IN THE RANGE OF 0.1-9.0, 1.0-15.0 AND 0.1-10.0 MG L-1 FOR ACETAMINOPHEN, IBUPROFEN AND CAFFEINE, RESPECTIVELY. LIMITS OF DETECTION WERE 0.04, 0.26 AND 0.04 MGL-1, RESPECTIVELY. THE RMSEP FOR ACETAMINOPHEN, IBUPROFEN AND CAFFEINE WITH PLS, OSC-PLS AND WOSC-PLS METHODS WERE 0.871, 0.685, 0.729 AND 0.124, 0.109, 0.112 AND 0.056, 0.031, 0.036, RESPECTIVELY. THE CAPABILITY OF THE METHOD FOR THE ANALYSIS OF REAL SAMPLES WAS EVALUATED BY THE DETERMINATION OF THESE DRUGS IN HUMAN PLASMA AND PHARMACEUTICAL SAMPLES WITH SATISFACTORY RESULTS.CONCLUSION: THE DEVELOPED METHOD IS SIMPLE, EFFECTIVE AND SENSITIVE AND VERY SUITABLE FOR DETERMINATION OF DRUGS. IN ORDER TO OVERCOME THE DRAWBACK OF SPECTRAL INTERFERENCES, WOSC-PLS AND OSC-PLS APPROACHES WERE APPLIED AND COMPARED. ANALYSIS OF THE RESULTS FOR TERNARY MIXTURES SHOWED THAT THE WOSC-PLS METHOD WAS MORE EFFECTIVE IN ENHANCING SUBSEQUENT PLS MODELS THAN PLS OR OSC-PLS METHODS.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

BERENJIAN, BAHAREH, & NIAZI, ALI. (2014). SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF ACETAMINOPHEN, IBUPROFEN AND CAFFEINE IN BIOLOGICAL AND DRUG SAMPLES USING WAVELET-OSC-PLS IBUPROFEN. IRANIAN CHEMISTRY CONGRESS. SID. https://sid.ir/paper/912285/en

Vancouver: Copy

BERENJIAN BAHAREH, NIAZI ALI. SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF ACETAMINOPHEN, IBUPROFEN AND CAFFEINE IN BIOLOGICAL AND DRUG SAMPLES USING WAVELET-OSC-PLS IBUPROFEN. 2014. Available from: https://sid.ir/paper/912285/en

IEEE: Copy

BAHAREH BERENJIAN, and ALI NIAZI, “SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF ACETAMINOPHEN, IBUPROFEN AND CAFFEINE IN BIOLOGICAL AND DRUG SAMPLES USING WAVELET-OSC-PLS IBUPROFEN,” presented at the IRANIAN CHEMISTRY CONGRESS. 2014, [Online]. Available: https://sid.ir/paper/912285/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops