ROLES OF HLA GENES AND HLA POLYMORPHISMS ON MULTIPLE SCLEROSIS PATHOGENESIS AND SUSCEPTIBILITY

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BOOZARPOUR SOHRAB; Kargar Dolatabadi Alireza; Jorjani Eisa

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL MS CONGRESS OF IRAN
Year:2015 | Issue:12

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Title

ROLES OF HLA GENES AND HLA POLYMORPHISMS ON MULTIPLE SCLEROSIS PATHOGENESIS AND SUSCEPTIBILITY

Author(s)

BOOZARPOUR SOHRAB | Kargar Dolatabadi Alireza | Jorjani Eisa

Keywords

MULTIPLE SCLEROSIS (MS)

AUTOIMMUNE DISEASE

HUMAN LEUKOCYTE ANTIGEN (HLA)

HLA POLYMORPHISMS

Abstract

INTRODUCTION: MULTIPLE SCLEROSIS (MS) IS A CHRONIC INFLAMMATORY, AUTOIMMUNE DISEASE OF THE BRAIN AND SPINAL CORD THAT LEADS TO NEUROLOGICAL DEFICIENCY. EPIDEMIOLOGIC EVIDENCE IN STUDIED MS ARTICLES SUGGESTS THAT ITS DEVELOPMENT DEPENDS ON GENETIC AND ENVIRONMENTAL FACTORS. THE HUMAN LEUKOCYTE ANTIGEN (HLA) SYSTEM IS THE LOCUS OF GENES THAT ENCODE FOR PROTEINS ON THE SURFACE OF CELLS THAT ARE RESPONSIBLE FOR REGULATION OF THE IMMUNE SYSTEM IN HUMANS. ASSOCIATION STUDIES ON GENOME-WIDE ASSOCIATION STUDIES (GWAS) HAVE BEEN CONDUCTED FOR MS AND OTHER AUTOIMMUNE DISEASES, AND HAVE IDENTIFIED SPECIFIC HLA GENES. IN THIS ARTICLE, WE REVIEW RECENT STUDIES THAT ILLUMINATE ROLES OF HLA GENES AND POLYMORPHISMS OF HLA GENES IN MS PATHOGENESIS AND SUSCEPTIBILITY.

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APA: Copy

BOOZARPOUR, SOHRAB, Kargar Dolatabadi, Alireza, & Jorjani, Eisa. (2015). ROLES OF HLA GENES AND HLA POLYMORPHISMS ON MULTIPLE SCLEROSIS PATHOGENESIS AND SUSCEPTIBILITY. INTERNATIONAL MS CONGRESS OF IRAN. SID. https://sid.ir/paper/921129/en

Vancouver: Copy

BOOZARPOUR SOHRAB, Kargar Dolatabadi Alireza, Jorjani Eisa. ROLES OF HLA GENES AND HLA POLYMORPHISMS ON MULTIPLE SCLEROSIS PATHOGENESIS AND SUSCEPTIBILITY. 2015. Available from: https://sid.ir/paper/921129/en

IEEE: Copy

SOHRAB BOOZARPOUR, Alireza Kargar Dolatabadi, and Eisa Jorjani, “ROLES OF HLA GENES AND HLA POLYMORPHISMS ON MULTIPLE SCLEROSIS PATHOGENESIS AND SUSCEPTIBILITY,” presented at the INTERNATIONAL MS CONGRESS OF IRAN. 2015, [Online]. Available: https://sid.ir/paper/921129/en

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