SIGNIFICANT ASSOCIATION BETWEEN MYELIN PROTEOLIPID PROTEIN (58-74) PUTATIVE EPITOPE AND MULTIPLE SCLEROSIS PATHOGENESIS

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SADEGHI MEHDI; Pouragahi Samie; ZAMANZADEH ZAHRA; ATAEI MITRA; NABAVI SEYED MASSOOD; SANATI MOHAMMAD HOSEIN; AHANGARI GHASEM

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL MS CONGRESS OF IRAN
Year:2015 | Issue:12

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Title

SIGNIFICANT ASSOCIATION BETWEEN MYELIN PROTEOLIPID PROTEIN (58-74) PUTATIVE EPITOPE AND MULTIPLE SCLEROSIS PATHOGENESIS

Author(s)

Keywords

MULTIPLE SCLEROSIS

MYELIN PROTEOLIPID PROTEIN

MOLECULAR MIMICRY

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

AUTOIMMUNE DISEASE

Abstract

BACKGROUND: MULTIPLE SCLEROSIS (MS) IS THE MOST COMMON AUTOIMMUNE DISEASE OF THE CENTRAL NERVOUS SYSTEM (CNS). THE MAIN CAUSE OF MS HASN’T REVEALED YET, BUT THE MOST PROBABLE THEORY IS ACCORDING TO THE MOLECULAR MIMICRY THAT CONCLUDED SOME INFECTIONS CAN ACTIVATE T CELLS AGAINST BRAIN AUTO-ANTIGENS AND INITIATE THE DISEASE CASCADE. MYELIN PROTEOLIPID PROTEIN (PLP) IS ONE OF THE BRAIN AUTO-ANTIGENS AND ITS RESTRICTION AND ABUNDANCE IN CNS, TURNS IT TO A PROPER CANDIDATE AS AN AUTO-ANTIGEN. THIS STUDY IS CONDUCTED TO EVALUATE OF PLP58-72 ACTIVATORY EFFECTS ON T LYMPHOCYTES AND HUMERAL IMMUNITY.

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APA: Copy

SADEGHI, MEHDI, Pouragahi, Samie, ZAMANZADEH, ZAHRA, ATAEI, MITRA, NABAVI, SEYED MASSOOD, SANATI, MOHAMMAD HOSEIN, & AHANGARI, GHASEM. (2015). SIGNIFICANT ASSOCIATION BETWEEN MYELIN PROTEOLIPID PROTEIN (58-74) PUTATIVE EPITOPE AND MULTIPLE SCLEROSIS PATHOGENESIS. INTERNATIONAL MS CONGRESS OF IRAN. SID. https://sid.ir/paper/921238/en

Vancouver: Copy

SADEGHI MEHDI, Pouragahi Samie, ZAMANZADEH ZAHRA, ATAEI MITRA, NABAVI SEYED MASSOOD, SANATI MOHAMMAD HOSEIN, AHANGARI GHASEM. SIGNIFICANT ASSOCIATION BETWEEN MYELIN PROTEOLIPID PROTEIN (58-74) PUTATIVE EPITOPE AND MULTIPLE SCLEROSIS PATHOGENESIS. 2015. Available from: https://sid.ir/paper/921238/en

IEEE: Copy

MEHDI SADEGHI, Samie Pouragahi, ZAHRA ZAMANZADEH, MITRA ATAEI, SEYED MASSOOD NABAVI, MOHAMMAD HOSEIN SANATI, and GHASEM AHANGARI, “SIGNIFICANT ASSOCIATION BETWEEN MYELIN PROTEOLIPID PROTEIN (58-74) PUTATIVE EPITOPE AND MULTIPLE SCLEROSIS PATHOGENESIS,” presented at the INTERNATIONAL MS CONGRESS OF IRAN. 2015, [Online]. Available: https://sid.ir/paper/921238/en

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