EVALUATION OF GENETIC ALTERATIONS IN EXON 5 OF RABL2B GENE IN INFERTILE MEN WITH IMMOTILE SHORT TAIL SPERM COMPARED TO CONTROL SUBJECTS

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HOSSEINI H.; Poursafari E.; MODARRESI T.; SABBAGHIAN M.; MOHSENI MEYBODI A.; SADIGHI GILANI M.A.

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Seminar Paper

Paper Information

Seminar: IRHRC ANNUAL MEETING REPRODUCTIVE AND INFERTILITY UPDATES
Year:2015 | Issue:7

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Title

EVALUATION OF GENETIC ALTERATIONS IN EXON 5 OF RABL2B GENE IN INFERTILE MEN WITH IMMOTILE SHORT TAIL SPERM COMPARED TO CONTROL SUBJECTS

Author(s)

Keywords

RABL2B GENE

IMMOTILE SHORT TAIL SPERM (ISTS)

MALE INFERTILITY

Abstract

BACKGROUND: THE IMMOTILE SHORT TAIL SPERM (ISTS) SYNDROME RESULTS IN MALE INFERTILITY. PATIENTS WITH ISTS HAVE IMMOTILE SHORT-TAILED SPERM WITH DISORGANIZED AXONEM. THEIR SPERM COUNT IS LOW TOO. ONE CANDIDATE GENE CAUSING THE SYNDROME IS RAB LIKE 2B (RABL2B). RECENTLY IT HAS BEEN SHOWN THAT MOUSE RABL2 HAS AN IMPORTANT ROLE IN SPERM TAIL ASSEMBLY AND MALE FERTILITY. RABL2B AS A HUMAN ORTHOLOGUE OF RABL2 CODES A PROTEIN WITH 228 AMINO ACIDS INCLUDED 4 GTP BINDING DOMAINS. EXON 5 CODES AN IMPORTANT GTP BINDING DOMAIN THAT HAS AN IMPORTANT ROLE IN PROTEIN FUNCTION. TO THE BEST OF OUR KNOWLEDGE, THERE HAVE NOT BEEN HUMAN STUDIES ABOUT ROLE OF RABL2B MUTATIONS IN SPERM ABNORMALITIES….

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APA: Copy

HOSSEINI, H., Poursafari, E., MODARRESI, T., SABBAGHIAN, M., MOHSENI MEYBODI, A., & SADIGHI GILANI, M.A.. (2015). EVALUATION OF GENETIC ALTERATIONS IN EXON 5 OF RABL2B GENE IN INFERTILE MEN WITH IMMOTILE SHORT TAIL SPERM COMPARED TO CONTROL SUBJECTS. IRHRC ANNUAL MEETING REPRODUCTIVE AND INFERTILITY UPDATES. SID. https://sid.ir/paper/924558/en

Vancouver: Copy

HOSSEINI H., Poursafari E., MODARRESI T., SABBAGHIAN M., MOHSENI MEYBODI A., SADIGHI GILANI M.A.. EVALUATION OF GENETIC ALTERATIONS IN EXON 5 OF RABL2B GENE IN INFERTILE MEN WITH IMMOTILE SHORT TAIL SPERM COMPARED TO CONTROL SUBJECTS. 2015. Available from: https://sid.ir/paper/924558/en

IEEE: Copy

H. HOSSEINI, E. Poursafari, T. MODARRESI, M. SABBAGHIAN, A. MOHSENI MEYBODI, and M.A. SADIGHI GILANI, “EVALUATION OF GENETIC ALTERATIONS IN EXON 5 OF RABL2B GENE IN INFERTILE MEN WITH IMMOTILE SHORT TAIL SPERM COMPARED TO CONTROL SUBJECTS,” presented at the IRHRC ANNUAL MEETING REPRODUCTIVE AND INFERTILITY UPDATES. 2015, [Online]. Available: https://sid.ir/paper/924558/en

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