THREE DIMENSIONAL FLUORESCENCE SPECTROSCOPY INVESTIGATION OF BINARY BETWEEN HUMAN SERUM ALBUMIN AND TWO NANOPARTICLE DRUGS

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Vahidzadeh M.; GHARANFOLI M.; CHAMANI J.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Paper Information

Seminar: INTERNATIONAL IRANIAN BIOLOGY CONFERENCE
Year:2012 | Issue:17

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Title

THREE DIMENSIONAL FLUORESCENCE SPECTROSCOPY INVESTIGATION OF BINARY BETWEEN HUMAN SERUM ALBUMIN AND TWO NANOPARTICLE DRUGS

Author(s)

Vahidzadeh M. | GHARANFOLI M. | CHAMANI J.

Keywords

HAS

COL

THREE DIMENSIONAL FLUORESCENCE SPECTROSCOPY BINARY AND TERNARY SYSTEMS

Abstract

THE INTRACTION BETWEEN COLCHICINE (COL) AND HUMAN SERUM ALBUMIN (HSA) IN THE PRESENCE OF ASPIRIN (ASA) AS TWO NANOPARTICLE DRUGS IN PHYSIOLOGICAL CONDITION (PH=7.4) WAS INVESTIGATED BY FLUORESCENCE SPECTROSCOPY. THE CHANGE ON THE PROTEIN CONFORMATION UPON BINDING WAS FOLLOWED AS A FUNCTION OF ADDED DRUG BY THREE-DIMENSIONAL. CHANGE IN THE ENVIRONMENT OF THE AROMATIC RESIDUES ARE ALSO OBSORVED. THE RESULTS INDICATED THAT THE STRUCTURE OF TRP AND TYR RESIDUES ENVIRONMENTS WAS ALTERED AND PHYSIOLOSICAL FUNCTION OF DRUGS WERE AFFECTED BY HSA. IT WAS SHOWN THAT THE FLUORESCENCE OF HSA HAVE BEEN QUENCHED FOR REACTING WITH DRUGS AND FORMING A CERTAIN KIND OF NEW COMPOUND. TREE-DIMENSIONAL FLUORESCENCE SPECTROSCOPY SHOWS THAT THE SECONDARY STRUCTURE OF HSA CHANGED AFTER DRUGS BOUND TO HSA IN BINARY AND TERNARY SYSTEMS.

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APA: Copy

Vahidzadeh, M., GHARANFOLI, M., & CHAMANI, J.. (2012). THREE DIMENSIONAL FLUORESCENCE SPECTROSCOPY INVESTIGATION OF BINARY BETWEEN HUMAN SERUM ALBUMIN AND TWO NANOPARTICLE DRUGS. INTERNATIONAL IRANIAN BIOLOGY CONFERENCE. SID. https://sid.ir/paper/929121/en

Vancouver: Copy

Vahidzadeh M., GHARANFOLI M., CHAMANI J.. THREE DIMENSIONAL FLUORESCENCE SPECTROSCOPY INVESTIGATION OF BINARY BETWEEN HUMAN SERUM ALBUMIN AND TWO NANOPARTICLE DRUGS. 2012. Available from: https://sid.ir/paper/929121/en

IEEE: Copy

M. Vahidzadeh, M. GHARANFOLI, and J. CHAMANI, “THREE DIMENSIONAL FLUORESCENCE SPECTROSCOPY INVESTIGATION OF BINARY BETWEEN HUMAN SERUM ALBUMIN AND TWO NANOPARTICLE DRUGS,” presented at the INTERNATIONAL IRANIAN BIOLOGY CONFERENCE. 2012, [Online]. Available: https://sid.ir/paper/929121/en

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