IN SILICO DETERMINATION AND VALIDATION OF PORA STRUCTURE AND LIGAND BINDING SITE AS A VACCINE CANDIDATE IN NEISSERIA MENINGITIDES

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Akhoondi Aghda Mohadese; Sefid Fateme; Rezaei Robabe; Mohitian Elahe; Mousavizadeh Fahime Sadat

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL CONFERENCE ON RESEARCH IN SCIENCE AND TECHNOLOGY
Year:2016 | Issue:2

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Title

IN SILICO DETERMINATION AND VALIDATION OF PORA STRUCTURE AND LIGAND BINDING SITE AS A VACCINE CANDIDATE IN NEISSERIA MENINGITIDES

Author(s)

Akhoondi Aghda Mohadese | Sefid Fateme | Rezaei Robabe | Mohitian Elahe | Mousavizadeh Fahime Sadat

Keywords

NEISSERIA MENINGITIDES

PORA

LIGAND BINDIG SITE

BIOINFORMATIC

Abstract

NEISSERIA MENINGITIDISIS A MAJOR CAUSE OF BACTERIALMENINGITIS AND SEPTICEMIA WORLDWIDE. IN THEABSENCE OF A COMPREHENSIVE VACCINE AGAINST THIS ORGANISM, THE CHARACTERIZATION OF ITS VARIABLE SURFACE ANTIGENS ISIMPORTANT FOR EPIDEMIOLOGIC MONITORING AND VACCINE DEVELOPMENT. THE SEROLOGIC CHARACTERIZATION SCHEMEFOR MENINGOCOCCI COMPRISES THE FOLLOWING: GROUPS, BASEDON VARIANTS IN THE CAPSULAR POLYSACCHARIDE, TYPES, BASED ONVARIANTS OF THE PORB OUTER MEMBRANE PROTEIN (OMP), SUBTYPES, BASED ON VARIANTS OF THE PORA OMP, AND IMMUNOTYPES, BASED ON VARIANTS IN THE LIPOOLIGOSACCHARIDE.THE DEVELOPMENT OF AN EFFECTIVE VACCINE AGAINST SEROGROUP B STRAINS, WHICH HAVE BEEN RESPONSIBLE FOR THE MAJORITY OF INFECTIONS IN TEMPERATE COUNTRIES, IS THEREFORE LIKELY TO REQUIRE ALTERNATIVE APPROACHES.THE TWO MAJOR COMPONENTS OF THE OMV VACCINE ARE THE MENINGOCOCCAL PORIN PROTEINS ENCODED BY THE PORA AND PORB GENES.IN ORDER TO STUDY THE VACCINE POTENTIAL OF INDIVIDUAL OUTER MEMBRANE PROTEINS, WE ANALYZE THE PORB STRUCTURE TO IDENTIFIED FUNCTIONAL RESIDUES WICHINVOLVED IN LIGAND BINDIG SITE.

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APA: Copy

Akhoondi Aghda, Mohadese, Sefid, Fateme, Rezaei, Robabe, Mohitian, Elahe, & Mousavizadeh, Fahime Sadat. (2016). IN SILICO DETERMINATION AND VALIDATION OF PORA STRUCTURE AND LIGAND BINDING SITE AS A VACCINE CANDIDATE IN NEISSERIA MENINGITIDES. INTERNATIONAL CONFERENCE ON RESEARCH IN SCIENCE AND TECHNOLOGY. SID. https://sid.ir/paper/929289/en

Vancouver: Copy

Akhoondi Aghda Mohadese, Sefid Fateme, Rezaei Robabe, Mohitian Elahe, Mousavizadeh Fahime Sadat. IN SILICO DETERMINATION AND VALIDATION OF PORA STRUCTURE AND LIGAND BINDING SITE AS A VACCINE CANDIDATE IN NEISSERIA MENINGITIDES. 2016. Available from: https://sid.ir/paper/929289/en

IEEE: Copy

Mohadese Akhoondi Aghda, Fateme Sefid, Robabe Rezaei, Elahe Mohitian, and Fahime Sadat Mousavizadeh, “IN SILICO DETERMINATION AND VALIDATION OF PORA STRUCTURE AND LIGAND BINDING SITE AS A VACCINE CANDIDATE IN NEISSERIA MENINGITIDES,” presented at the INTERNATIONAL CONFERENCE ON RESEARCH IN SCIENCE AND TECHNOLOGY. 2016, [Online]. Available: https://sid.ir/paper/929289/en

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