ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE CONJUGATED C595 MONOCLONAL ANTIBODY AS T2 CONTRAST AGENT BY USING MR IMAGING

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Moradi Khaniabadi Pegah; SHAHBAZI GAHROUEI D.; Majid AMSA; JAAFAR M.S.; MORADI KHANIABADI BITA

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL CONFERENCE ON RESEARCH IN SCIENCE AND TECHNOLOGY
Year:2016 | Issue:2

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Title

ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE CONJUGATED C595 MONOCLONAL ANTIBODY AS T2 CONTRAST AGENT BY USING MR IMAGING

Author(s)

Moradi Khaniabadi Pegah | SHAHBAZI GAHROUEI D. | Majid AMSA | JAAFAR M.S. | MORADI KHANIABADI BITA

Keywords

MAGNETIC PARTICLE

ANTIBODY CONJUGATION

CONTRAST AGENT

MAGNETIC RESONANCE IMAGING

Abstract

ADVANCES OF NANOTECHNOLOGY HAVE LED TO THE DEVELOPMENT OF NANOMATERIALS WITH BOTH POTENTIAL DIAGNOSTIC AND THERAPEUTIC APPLICATIONS. AMONG THEM, SUPERPARAMAGNETIC IRON OXIDE (SPIO) NANOPATERIALS HAVE RECEIVED PARTICULAR ATTENTION. WHEN SPIOS ARE USED AS CARRIER VEHICLE, ADDITIONAL ADVANTAGED CAN BE ACHIEVED INCLUDING MONITORING WITH. IRON OXIDE PARTICLES ARE TYPICALLY FUNCTIONALIZED WITH MANY BIOLOGICALLY ACTIVE MOLECULES LIKE TARGETING MOIETIES OF PEPTIDES OR DERIVATIONS OF ANTIBODY. MODIFIED EDC COUPLING FRACTION USED TO FABRICATE THE USPIO-C595 AS A MR IMAGING CONTRAST AGENT FOR BREAST CANCER TUMOR IN EARLY STAGES. FOURIER TRANSFORM INFRARED SPECTROSCOPY (FT-IR), TRANSMISSION ELECTRON MICROSCOPY (TEM), PCS WERE PERFORMED TO DETERMINE THE NANOPARTICLE BINDING. MAGNETIC RESONANCE IMAGING (MRI) WAS PERFORMED TO EVALUATE THE SIGNAL ENHANCEMENT ON T2 SPIN ECHO OF THE NANOPROBE. PROTEIN AND IRON CONCENTRATION OF NANOPROBE EXAMINED BY THE STANDARD METHOEDS. MTT ASSAY PERFORMED TO EVALUATE THE CYTOTOXICITY OF THE PROBE IN BREAST CANCER CELL LINE (MCF-7). BASED ON THE FINDINGS, LOW CONCENTRATION OF NANOPROBE CAUSED REDUCING THE T2 NOTABLY. ACCORDING TO THE INVESTIGATIONS FROM THE PRESENT RESEARCH USPIO-C595 NANOPROBE MAY PERHAPS BE THE POTENTIAL T2 BREAST MOLECULAR IMAGING TOGETHER WITH THE THERAPEUTIC AGENT.

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APA: Copy

Moradi Khaniabadi, Pegah, SHAHBAZI GAHROUEI, D., Majid, AMSA, JAAFAR, M.S., & MORADI KHANIABADI, BITA. (2016). ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE CONJUGATED C595 MONOCLONAL ANTIBODY AS T2 CONTRAST AGENT BY USING MR IMAGING. INTERNATIONAL CONFERENCE ON RESEARCH IN SCIENCE AND TECHNOLOGY. SID. https://sid.ir/paper/929401/en

Vancouver: Copy

Moradi Khaniabadi Pegah, SHAHBAZI GAHROUEI D., Majid AMSA, JAAFAR M.S., MORADI KHANIABADI BITA. ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE CONJUGATED C595 MONOCLONAL ANTIBODY AS T2 CONTRAST AGENT BY USING MR IMAGING. 2016. Available from: https://sid.ir/paper/929401/en

IEEE: Copy

Pegah Moradi Khaniabadi, D. SHAHBAZI GAHROUEI, AMSA Majid, M.S. JAAFAR, and BITA MORADI KHANIABADI, “ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE CONJUGATED C595 MONOCLONAL ANTIBODY AS T2 CONTRAST AGENT BY USING MR IMAGING,” presented at the INTERNATIONAL CONFERENCE ON RESEARCH IN SCIENCE AND TECHNOLOGY. 2016, [Online]. Available: https://sid.ir/paper/929401/en

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