THE TRANSCRIPTIONAL EFFECT OF HISTONE DEACETYLASE INHIBITOR OXAMFLATIN ON THE E-CADHERIN EXPRESSION IN GASTRIC CANCER CELL LINE

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FAGHIHLOO EBRAHIM; Araei Y.; MOKHTARI AZAD T.

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Seminar Paper

Paper Information

Seminar: INTERNATIONAL GASTROINTESTINAL CANCER CONGRESS
Year:2016 | Issue:3

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Title

THE TRANSCRIPTIONAL EFFECT OF HISTONE DEACETYLASE INHIBITOR OXAMFLATIN ON THE E-CADHERIN EXPRESSION IN GASTRIC CANCER CELL LINE

Author(s)

FAGHIHLOO EBRAHIM | Araei Y. | MOKHTARI AZAD T.

Keywords

OXAMFLATIN

E-CADHERIN

MKN-45 CELL LINE

GASTRIC CANCER

Abstract

INTRODUCTION & AIM: GASTRIC CANCER IS AMONG THE LEADING CAUSES OF CANCER-RELATED DEATH, AND THE SYMPTOMS ARE COMMONLY CHARACTERIZED IN ADVANCED STAGES. HISTONE ACETYLATION IS AMONG THE MOST IMPORTANT EPIGENETIC ALTERATIONS OCCURRING DURING CANCER DEVELOPMENT. IN ADDITION, REDUCED E-CADHERIN EXPRESSION IS A MAJOR CONTRIBUTOR IN THE PROCESS OF TUMOR CELL INVASION AND METASTASIS. OXAMFLATIN IS A HISTONE DEACETYLASE INHIBITOR THAT HAS BEEN SUGGESTED AS A PROMISING ANTI-TUMOR AGENT; YET ITS EFFECT ON THE VIABILITY AND INVASION OF GASTRIC TUMOR CELLS IS UNCLEAR. WE AIMED TO ASSESS THE IMPACT OF OXAMFLATIN ON THE VIABILITY OF GASTRIC TUMOR CELLS AND EXPRESSION OF E-CADHERIN AS A MARKER OF TUMOR INVASION SUSCEPTIBILITY...

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APA: Copy

FAGHIHLOO, EBRAHIM, Araei, Y., & MOKHTARI AZAD, T.. (2016). THE TRANSCRIPTIONAL EFFECT OF HISTONE DEACETYLASE INHIBITOR OXAMFLATIN ON THE E-CADHERIN EXPRESSION IN GASTRIC CANCER CELL LINE. INTERNATIONAL GASTROINTESTINAL CANCER CONGRESS. SID. https://sid.ir/paper/936363/en

Vancouver: Copy

FAGHIHLOO EBRAHIM, Araei Y., MOKHTARI AZAD T.. THE TRANSCRIPTIONAL EFFECT OF HISTONE DEACETYLASE INHIBITOR OXAMFLATIN ON THE E-CADHERIN EXPRESSION IN GASTRIC CANCER CELL LINE. 2016. Available from: https://sid.ir/paper/936363/en

IEEE: Copy

EBRAHIM FAGHIHLOO, Y. Araei, and T. MOKHTARI AZAD, “THE TRANSCRIPTIONAL EFFECT OF HISTONE DEACETYLASE INHIBITOR OXAMFLATIN ON THE E-CADHERIN EXPRESSION IN GASTRIC CANCER CELL LINE,” presented at the INTERNATIONAL GASTROINTESTINAL CANCER CONGRESS. 2016, [Online]. Available: https://sid.ir/paper/936363/en

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