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Information Journal Paper

Title

High-Intensity Interval Training Through mTOR and SREBP1 Proteins leads to the Regulation of Adipose Tissue in Rats Obese with Type 2 Diabetes

Pages

  41-48

Abstract

 Introduction: The mTOR and SREBP1 proteins are key proteins in the metabolism and Adipose tissue regulation. Obesity and type 2 diabetes can disorder with the function of these two proteins. The purpose of the present study was to investigatethe effect of High-intensity interval training on the content of mTOR and SREBP1 proteins in subcutaneous fat tissue in obese Type 2 diabetic male Sprague-Dawley rats with diabetes. Methods: In this experimental study, 16 two-month-old Sprague-Dawley rats with a mean weight of 300± 20 g were selected. After diabetic induction with STZ and Nicotinamide, rats were randomly assigned to two groups, diabetic training (8 heads) and diabetic control (8 heads). The training group trained HIIT for 4 days a week in accordance with the training programfor 8 weeks, while the control group did not have any training program. The independent t-test was used to analyze the data. Results: There was a significant increase in the content of mTOR (P=0. 001) and SREBP1 (P=0. 001) proteins in the traininggroup compared to control; The control group weight (P=0. 001) and training group (P=0. 009) significantly increased atthe end of the eighth week compared to the first week; Also, blood glucose levels in the control group showed a significant increase in the 8th week compared to the first week (P=0. 001). But in the training group at the end of the eighth week, it waslower than the first week (P=0. 001). Conclusion: Endurance training can adjust the weight, blood glucose and proteins content of mTOR and SREBP1; therefore, the HIIT exercise can be a good way to regulate metabolism and Adipose tissue.

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    APA: Copy

    ZAREI, FATEMEH, & JAFARI, AKRAM. (2020). High-Intensity Interval Training Through mTOR and SREBP1 Proteins leads to the Regulation of Adipose Tissue in Rats Obese with Type 2 Diabetes. KNOWLEDGE AND HEALTH, 15(1 ), 41-48. SID. https://sid.ir/paper/950098/en

    Vancouver: Copy

    ZAREI FATEMEH, JAFARI AKRAM. High-Intensity Interval Training Through mTOR and SREBP1 Proteins leads to the Regulation of Adipose Tissue in Rats Obese with Type 2 Diabetes. KNOWLEDGE AND HEALTH[Internet]. 2020;15(1 ):41-48. Available from: https://sid.ir/paper/950098/en

    IEEE: Copy

    FATEMEH ZAREI, and AKRAM JAFARI, “High-Intensity Interval Training Through mTOR and SREBP1 Proteins leads to the Regulation of Adipose Tissue in Rats Obese with Type 2 Diabetes,” KNOWLEDGE AND HEALTH, vol. 15, no. 1 , pp. 41–48, 2020, [Online]. Available: https://sid.ir/paper/950098/en

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