INVESTIGATION THE RESPONSE OF SOME PROTEINS THAT INVOLVED IN CACHEXIA SYNDROME TO ACUTE RESISTANCE EXERCISE IN HEALTHY ELDERLY PEOPLE

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GHOLAMALI MEYSAM; SHABANI MOHSEN; HEDAYATI MEHDI

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Journal: Salmand: Iranian Journal of Ageing Year:2015 | Volume:9 | Issue:4 Page(s): 288-296

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Title

INVESTIGATION THE RESPONSE OF SOME PROTEINS THAT INVOLVED IN CACHEXIA SYNDROME TO ACUTE RESISTANCE EXERCISE IN HEALTHY ELDERLY PEOPLE

Author(s)

GHOLAMALI MEYSAM | SHABANI MOHSEN | HEDAYATI MEHDI | Issue Writer Certificate

Keywords

MYOSTATINQ2

IGF-1Q2

CACHEXIAQ2

ELDERLY MENQ2

Abstract

Background: The aim of this study was to investigate the response of plasma MYOSTATIN and insulin growth factor like-1 (IGF-1), as two of the most important proteins involved in CACHEXIA syndrome, to acute resistance exercise in healthy elderly people.Methods & Materials: Twelve healthy older men (Age=67±1.3 years, BMI=25±1.4 kg/m2) volunteered for participation in this study. 72 hours after the determination of muscular maximal strength (by 1-RM test), subjects participated in acute resistance exercises via 75% 1-RM. In this research, two blood samples were collected at before and immediately after the exercise from Antecubital vein. Plasma MYOSTATIN and serum levels of IGF-1 were measured by ELISA methods. Paired T-Test used for statical analyses of research data. Significant level was set at P≤0.05.Results The results of this study showed that plasma MYOSTATIN significantly decreased in response to resistance exercise (P=0.0001). Also the serum levels of IGF-1 increased significantly in response to resistance exercise (P=0.0001). In turn, the results revealed that the IGF-1 to MYOSTATIN ratio increased significantly in response to resistance exercise (P=0.001).Conclusion: The results of this study showed that resistance exercise through increases of IGF-1 and decreases of MYOSTATIN causes increment of IGF-1 to MYOSTATIN ratio. According to the results of this study it seems prescription of resistance exercise could positive changes in proteins that involved in CACHEXIA syndrome in elderly people. Presumably, through this way we can prevent from CACHEXIA and its many physiological and physical related dysfunctions in theses people.

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APA: Copy

GHOLAMALI, MEYSAM, SHABANI, MOHSEN, & HEDAYATI, MEHDI. (2015). INVESTIGATION THE RESPONSE OF SOME PROTEINS THAT INVOLVED IN CACHEXIA SYNDROME TO ACUTE RESISTANCE EXERCISE IN HEALTHY ELDERLY PEOPLE. IRANIAN JOURNAL OF AGEING, 9(4), 288-296. SID. https://sid.ir/paper/95103/en

Vancouver: Copy

GHOLAMALI MEYSAM, SHABANI MOHSEN, HEDAYATI MEHDI. INVESTIGATION THE RESPONSE OF SOME PROTEINS THAT INVOLVED IN CACHEXIA SYNDROME TO ACUTE RESISTANCE EXERCISE IN HEALTHY ELDERLY PEOPLE. IRANIAN JOURNAL OF AGEING[Internet]. 2015;9(4):288-296. Available from: https://sid.ir/paper/95103/en

IEEE: Copy

MEYSAM GHOLAMALI, MOHSEN SHABANI, and MEHDI HEDAYATI, “INVESTIGATION THE RESPONSE OF SOME PROTEINS THAT INVOLVED IN CACHEXIA SYNDROME TO ACUTE RESISTANCE EXERCISE IN HEALTHY ELDERLY PEOPLE,” IRANIAN JOURNAL OF AGEING, vol. 9, no. 4, pp. 288–296, 2015, [Online]. Available: https://sid.ir/paper/95103/en

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