The effect of eight weeks moderate-intensity endurance training on hypocampic brain-derived neurotrophic factor and tyrosine kinase B receptor gene expression in the rats with hippocampal degeneration model

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AKBARI F.; MOGHADASI M.; FARSI S.; EDALATMANESH M.A.

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Journal: JOURNAL OF METABOLISM AND EXERCISE Year:2019 | Volume:9 | Issue:2 Page(s): 137-147

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Title

The effect of eight weeks moderate-intensity endurance training on hypocampic brain-derived neurotrophic factor and tyrosine kinase B receptor gene expression in the rats with hippocampal degeneration model

Author(s)

AKBARI F. | MOGHADASI M. | FARSI S. | EDALATMANESH M.A. | Issue Writer Certificate

Keywords

Endurance training

Brain-derived neurotrophic factor

Tyrosine kinase B receptor

Hippocampus

Alzheimer disease

Abstract

Aim: Alzheimer disease is characterized by progressive cognitive decline accompanied with hypocampic neurotrophins reduction. The effects of exercise on hypocampic changes in these patients are not well known. The purpose of the present study was to examine the effect of eight weeks moderate-intensity Endurance training on hypocampic Brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) receptor gene expression in the rats with hippocampal degeneration model. Method: In this experiment, twenty-four mature Sprague-dawley male rats were subjected to Alzheimer’ s disease through intraperitoneally injection of 8 mg/kg Trimethytin (TMT) and then were divided into (1) Alzheimer-infected control group, (2) Endurance training, and (3) sham to study the impact of the disease on the variables. Sixteen healthy rats were assigned to the control group that eight rats sacrifice at first week and eight rats sacrifice at last week. The rats in the Endurance training group ran on a treadmill with the speed of 15 to 20 meters per minute for 15 to 30 minutes in each session, 3 times a week for 8 weeks. To analyze the results, one-way ANOVA and Tukey post hoc test were run using SPSS. Results: The results revealed that induction of Alzheimer’ s disease by TMT decreases the BDNF (P=0. 001) and TrkB receptor (P=0. 001) gene expression in rats. The results, also indicated that there were no significant differences in hypocampic BDNF (P=0. 25) and TrkB receptor (P=0. 99) gene expression between Endurance training group and sham group. Conclusion: According to the study results, it seems that Endurance training with specific intensity and duration utilized in this study had not significant effect on changes of hypocampic BDNF and TrkB receptor gene expression in the rats with hippocampal degeneration model. Further studies are needed in this field.

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APA: Copy

AKBARI, F., MOGHADASI, M., FARSI, S., & EDALATMANESH, M.A.. (2019). The effect of eight weeks moderate-intensity endurance training on hypocampic brain-derived neurotrophic factor and tyrosine kinase B receptor gene expression in the rats with hippocampal degeneration model. JOURNAL OF METABOLISM AND EXERCISE, 9(2 ), 137-147. SID. https://sid.ir/paper/951203/en

Vancouver: Copy

AKBARI F., MOGHADASI M., FARSI S., EDALATMANESH M.A.. The effect of eight weeks moderate-intensity endurance training on hypocampic brain-derived neurotrophic factor and tyrosine kinase B receptor gene expression in the rats with hippocampal degeneration model. JOURNAL OF METABOLISM AND EXERCISE[Internet]. 2019;9(2 ):137-147. Available from: https://sid.ir/paper/951203/en

IEEE: Copy

F. AKBARI, M. MOGHADASI, S. FARSI, and M.A. EDALATMANESH, “The effect of eight weeks moderate-intensity endurance training on hypocampic brain-derived neurotrophic factor and tyrosine kinase B receptor gene expression in the rats with hippocampal degeneration model,” JOURNAL OF METABOLISM AND EXERCISE, vol. 9, no. 2 , pp. 137–147, 2019, [Online]. Available: https://sid.ir/paper/951203/en

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