The effect of intense aerobic training on ICAM-1, VCAM-1 and RAGE expression in heart tissue in type 2 diabetes obese rats

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Bagheri Afsariehee Mohammad Reza; Banaifar Abdolali; ARSHADI SAJAD; SOHEILI SHAHRAM

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2020 | Volume:63 | Issue:4 Page(s): 2529-2540

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Title

The effect of intense aerobic training on ICAM-1, VCAM-1 and RAGE expression in heart tissue in type 2 diabetes obese rats

Author(s)

Bagheri Afsariehee Mohammad Reza | Banaifar Abdolali | ARSHADI SAJAD | SOHEILI SHAHRAM | Issue Writer Certificate

Keywords

Intense aerobic training

RAGE gene expression

ICAM-1 gene expression

VCAM-1 gene expression

Type 2 diabetes

Abstract

Introduction: The expression of adhesion molecules in the heart tissue is considered as an important indicator in the estimation of coronary artery disease risk. Since physical activity is effective in reducing symptoms of cardiac disease, The purpose of this study was to The effect of Intense aerobic training on gene expression ICAM-1, VCAM-1 and RAGE in heart tissue in Type 2 diabetes obese rats. Materials & Methods: During this experiment 14 diabetic rats with HighDieting Diet Vistar race with an average weight of 220 ± 20 grams, were randomly divided into two groups, including the control group, and the group intense aerobic. The training program of the Intense aerobic training group for 6 weeks was 5 sessions per week in the form of running on a treadmill with 30 second repetitions and 2 minute active rest between each repetition. Blood sampling was performed 48 hours after the last training session. test data were analyzed by Independent Samples t test. Results: The results showed that intense aerobic exercise have significant effect on gene expression ICAM-1 and VCAM-1(P=0/001). However, it had no significant effect on gene expression RAGE(P=0/34). Conclusion: According to the results, in seems that Intense aerobic trainings effectively reduce gene expressions ICAM-1 and VCAM-1 in left ventricular heart of diabetic rats and therefore can be considered an effective way in reducing pathogenesis cardiac signaling pathways in the heart of rats with Type 2 diabetes.

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APA: Copy

Bagheri Afsariehee, Mohammad Reza, Banaifar, Abdolali, ARSHADI, SAJAD, & SOHEILI, SHAHRAM. (2020). The effect of intense aerobic training on ICAM-1, VCAM-1 and RAGE expression in heart tissue in type 2 diabetes obese rats. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 63(4 ), 2529-2540. SID. https://sid.ir/paper/951279/en

Vancouver: Copy

Bagheri Afsariehee Mohammad Reza, Banaifar Abdolali, ARSHADI SAJAD, SOHEILI SHAHRAM. The effect of intense aerobic training on ICAM-1, VCAM-1 and RAGE expression in heart tissue in type 2 diabetes obese rats. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;63(4 ):2529-2540. Available from: https://sid.ir/paper/951279/en

IEEE: Copy

Mohammad Reza Bagheri Afsariehee, Abdolali Banaifar, SAJAD ARSHADI, and SHAHRAM SOHEILI, “The effect of intense aerobic training on ICAM-1, VCAM-1 and RAGE expression in heart tissue in type 2 diabetes obese rats,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 63, no. 4 , pp. 2529–2540, 2020, [Online]. Available: https://sid.ir/paper/951279/en

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