Response of Liver Tissue Bax and Bcl-2 Gene Expression to Aerobic Training with L-Carnitine Supplementation in Rats Toxicated by Boldenone

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Ahmadi Mozhgan; ABBASSI DALOII ASIEH; Salehi Kiasari Samira

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Journal: Complementary Medicine Journal Year:2020 | Volume:9 | Issue:4 (33) Page(s): 3890-3901

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Title

Response of Liver Tissue Bax and Bcl-2 Gene Expression to Aerobic Training with L-Carnitine Supplementation in Rats Toxicated by Boldenone

Author(s)

Ahmadi Mozhgan | ABBASSI DALOII ASIEH | Salehi Kiasari Samira | Issue Writer Certificate

Keywords

Aerobic training

Boldenone

Lcarnitine

Apoptosis

Wistar rats

Abstract

Objective: This study aimed to compare the response of liver tissue BAX and BCL-2 gene expression to Aerobic training with L-carnitine supplementation in rats intoxicated by Boldenone. Methods: In this experimental study, 30 male Wistar rats, aged 12 weeks (weight 195± 7. 94 g) were randomly divided into five groups: Control, no-treatment, Boldenone (5 mg/kg), L-carnitine (100 mg/kg) and Aerobic training-L-carnitine. The moderate endurance intensity training program (50%-55% of maximal oxygen consumption) performed for 6 weeks and 5 times a week. Injection once a week in the quadriceps and hamstring was conducted in-depth. After anesthesia, an autopsy was performed, and the liver Isolated. The hepatic Apoptosis gene expression in the samples was measured by Real-Time PCR. Data were analyzed by 1-way ANOVA and post hoc Scheffe at the significant level P<0. 05. Results: Significant difference was observed between the mean expression of BAX and BCL-2 in the liver tissue of male Wistar rats in different groups (P=0. 001). The BAX gene expression of the liver tissue in L-carnitine-Aerobic training and L-carnitine groups was significantly lower than the Boldenon group (P=0. 001). Also, The BCL-2 gene expression in L-carnitine-aerobic exercise and L-carnitine groups was significantly higher than the Boldenon group (P=0. 001). Conclusion: According to the findings of this study, supplementation of L-carnitine with regular Aerobic training can have a protective effect against Apoptosis induced by anabolic-androgenic steroids.

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APA: Copy

Ahmadi, Mozhgan, ABBASSI DALOII, ASIEH, & Salehi Kiasari, Samira. (2020). Response of Liver Tissue Bax and Bcl-2 Gene Expression to Aerobic Training with L-Carnitine Supplementation in Rats Toxicated by Boldenone. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, 9(4 (33) ), 3890-3901. SID. https://sid.ir/paper/952645/en

Vancouver: Copy

Ahmadi Mozhgan, ABBASSI DALOII ASIEH, Salehi Kiasari Samira. Response of Liver Tissue Bax and Bcl-2 Gene Expression to Aerobic Training with L-Carnitine Supplementation in Rats Toxicated by Boldenone. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY[Internet]. 2020;9(4 (33) ):3890-3901. Available from: https://sid.ir/paper/952645/en

IEEE: Copy

Mozhgan Ahmadi, ASIEH ABBASSI DALOII, and Samira Salehi Kiasari, “Response of Liver Tissue Bax and Bcl-2 Gene Expression to Aerobic Training with L-Carnitine Supplementation in Rats Toxicated by Boldenone,” COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, vol. 9, no. 4 (33) , pp. 3890–3901, 2020, [Online]. Available: https://sid.ir/paper/952645/en

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