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Information Journal Paper

Title

Association of G276T Polymorphism from Adiponectin Gene with Breast Cancer: A Case-Control Study

Pages

  8-14

Abstract

 Introduction: Adiponectin hormone is involved in modulating metabolic processes such as glucose regulation and fatty acid catabolism. Several single nucleotide Polymorphisms (SNPs) in the transcription region of the gene and its sequences have been identified in different populations that are associated with the prevalence of various diseases. The aim of this study was to determine frequency of G276T Polymorphism in Breast Cancer patients and its comparing in subjects without Breast Cancer. Material and Methods: 128 individuals with Breast Cancer and 128 healthy people were selected after the approval of a specialist physician. After blood collection and DNA extraction, all specimens were amplified with specific primers, then part of them was cut with Mva1269I enzyme and the genotypes of individuals were determined. The results were analyzed using IBM SPSS version 23 software by chi-square and logistic regression tests. Results: The two groups did not have a significant difference for mean age and body mass index. GT genotype was significantly different between the two groups and increased the risk of Breast Cancer by 1. 86 folds in their carriers. None of the genotypes had any relationship with histopathological changes. Conclusion: The T mutant allele at G276T position of Adiponectin had a decreasing effect on Breast Cancer, indicating that this result needs to be investigated in different populations with a larger sample size for confirmation.

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    APA: Copy

    TAHMASEBI FARD, ZAHRA. (2019). Association of G276T Polymorphism from Adiponectin Gene with Breast Cancer: A Case-Control Study. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 17(2 ), 8-14. SID. https://sid.ir/paper/952671/en

    Vancouver: Copy

    TAHMASEBI FARD ZAHRA. Association of G276T Polymorphism from Adiponectin Gene with Breast Cancer: A Case-Control Study. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2019;17(2 ):8-14. Available from: https://sid.ir/paper/952671/en

    IEEE: Copy

    ZAHRA TAHMASEBI FARD, “Association of G276T Polymorphism from Adiponectin Gene with Breast Cancer: A Case-Control Study,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 17, no. 2 , pp. 8–14, 2019, [Online]. Available: https://sid.ir/paper/952671/en

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