The effect of high-intensity interval training (HIIT) on syd and murf1 gene expression in skeletal muscle of diabetic rats

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JAFARI AHMAD; Ahmadi Mozhgan; Shadmehri Saeedeh

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Journal Paper

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Journal: Journal of Neyshabur University of Medical Sciences Year:2019 | Volume:7 | Issue:3 (24) Page(s): 119-130

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Information Journal Paper

Title

The effect of high-intensity interval training (HIIT) on syd and murf1 gene expression in skeletal muscle of diabetic rats

Author(s)

JAFARI AHMAD | Ahmadi Mozhgan | Shadmehri Saeedeh | Issue Writer Certificate

Keywords

diabetesh-intensity interval training

syd

murf1

Abstract

Introduction syd and murf1 are important molecular markers for muscle atrophy that increase significantly in skeletal muscle in various conditions, such as diabetes. The aim of this study was to evaluate the effect of high-intensity interval training (HIIT) on syd and murf1 genes expression in skeletal muscle of diabetic rats. Materials and Methods To the implementation of this experimental research, 60 male Wistar rats weighing 220 ± 20 gr randomly were divided into 5 groups including baseline control, eight-week control, diabetes, training, and diabetes-training. In this study, the rats were diabetic using given a single dose of 50 mg/ kg per body weight and peritoneal injection streptozotocin. High-intensity interval training performed on the treadmill with intensity of 80-85% VO2max, 5 days a week and for 8 weeks. The expression of syd and murf1 genes were measured by Real-Time PCR. Data were analyzed by one-way ANOVA and Bonferroni's post hoc test at the p<0. 05. Results The changes in the expression of murf1 and syd genes of the skeletal muscle in the diabetes group were significantly higher than the control group (P=0. 001). The high-intensity interval training significantly reduced the expression of murf1 and syd genes (P=0. 001). Conclusion HIIT may help reduce atrophy in diabetic patients by reducing the expression of syd and murf1 genes in skeletal muscle.

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APA: Copy

JAFARI, AHMAD, Ahmadi, Mozhgan, & Shadmehri, Saeedeh. (2019). The effect of high-intensity interval training (HIIT) on syd and murf1 gene expression in skeletal muscle of diabetic rats. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, 7(3 (24) ), 119-130. SID. https://sid.ir/paper/952942/en

Vancouver: Copy

JAFARI AHMAD, Ahmadi Mozhgan, Shadmehri Saeedeh. The effect of high-intensity interval training (HIIT) on syd and murf1 gene expression in skeletal muscle of diabetic rats. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;7(3 (24) ):119-130. Available from: https://sid.ir/paper/952942/en

IEEE: Copy

AHMAD JAFARI, Mozhgan Ahmadi, and Saeedeh Shadmehri, “The effect of high-intensity interval training (HIIT) on syd and murf1 gene expression in skeletal muscle of diabetic rats,” JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, vol. 7, no. 3 (24) , pp. 119–130, 2019, [Online]. Available: https://sid.ir/paper/952942/en

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