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Information Journal Paper

Title

The effect of eight weeks of aerobic training and Ritalin on hippocampus Brain-derived neurotrophic factor in hyperactive rats

Pages

  3628-3641

Abstract

 Introduction: Recently increased an expansion of interest in non-pharmacological interventions for attention-deficit/Hyperactivity disorder. The aim of this study to investigate the effect of eight weeks of aerobic training and Ritalin on Hippocampus Brain-derived neurotrophic factor in hyperactive Rats. Methods: To implementation of this experimental research, 33 Wistar Rats (weigh, 180-220g) were randomly divided into 5 groups: 1) Healthy control, 2) Hyperactivity, 3) Hyperactivity-Aerobic training, 4) Hyperactivity-Ritalin, and 5) Hyperactivity-Aerobic training-Ritalin and returned to the open field test. To induce ADHD in the Rats, injected 10 mg/kg of L-NAME for 8 weeks and 6 days per week based on weight of the Rats. The drug group received 1 mg oral Ritalin per kg weight of Rats daily for 8 weeks. The Rats performed aerobic training 30 minutes at day and 7 days of week for 8 weeks. The level of the Hippocampus BDNF was measured using ELISA kit. Data were analyzed by ANCOVA, one-way ANOVA and Tukey post hoc test at p≤ 0. 05. Results: The results showed that aerobic training led to significant increase in the levels of hippocampal BDNF in hyperactive Rats (p<0. 05). Ritalin increased the level of hippocampal BDNF in hyperactive Rats (p=0. 001). Also, Aerobic training with Ritalin significantly increased the level of hippocampal BDNF in hyperactive Rats (p=0. 001). Conclusion: Aerobic training with Ritalin led to increase in the level of hippocampal BDNF in hyperactive Rats.

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    APA: Copy

    SHADMEHRI, S., AHMADI, M., ABBASSI DALOII, A., & ZIAOLHAGH, S.J.. (2019). The effect of eight weeks of aerobic training and Ritalin on hippocampus Brain-derived neurotrophic factor in hyperactive rats. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, 9(1 (30) ), 3628-3641. SID. https://sid.ir/paper/954238/en

    Vancouver: Copy

    SHADMEHRI S., AHMADI M., ABBASSI DALOII A., ZIAOLHAGH S.J.. The effect of eight weeks of aerobic training and Ritalin on hippocampus Brain-derived neurotrophic factor in hyperactive rats. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY[Internet]. 2019;9(1 (30) ):3628-3641. Available from: https://sid.ir/paper/954238/en

    IEEE: Copy

    S. SHADMEHRI, M. AHMADI, A. ABBASSI DALOII, and S.J. ZIAOLHAGH, “The effect of eight weeks of aerobic training and Ritalin on hippocampus Brain-derived neurotrophic factor in hyperactive rats,” COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, vol. 9, no. 1 (30) , pp. 3628–3641, 2019, [Online]. Available: https://sid.ir/paper/954238/en

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