THE EFFECT OF PRE-NUTRITION OF HYDRO ALCOHOLIC EXTRACT OF ORIGANUM VULGARE ON BRAIN EDEMA AND NEUROLOGIC DEFICITS IN A RAT STROKE MODEL

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FOROOZANDEH MEYSAM; BIGDELI MOHAMMAD REZA; RAHNEMA MEHDI

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Journal: Journal of Birjand University of Medical Sciences Year:2015 | Volume:22 | Issue:3 Page(s): 209-217

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Title

THE EFFECT OF PRE-NUTRITION OF HYDRO ALCOHOLIC EXTRACT OF ORIGANUM VULGARE ON BRAIN EDEMA AND NEUROLOGIC DEFICITS IN A RAT STROKE MODEL

Author(s)

FOROOZANDEH MEYSAM | BIGDELI MOHAMMAD REZA | RAHNEMA MEHDI | Issue Writer Certificate

Keywords

ORIGANUM VULGAREQ1

STROKEQ2

BRAIN EDEMAQ2

NEUROLOGIC DEFICITSQ2

ANTIOXIDANTSQ2

Abstract

Background and Aim: STROKE is one of the most important factors of mortality and disability in the world. Free radicals are produced following ischemic STROKE and they play a central role in breaking the blood-brain barrier and causing BRAIN EDEMA formation.The aim of the current study was to evaluate the effect of hydro- alcoholic extract of ORIGANUM VULGARE on BRAIN EDEMA and neurologic deficit in a rat STROKE model.Materials and Methods: In this experimental study, 35 male Wistar rats were randomly divided into 5 equal groups. The first two groups (control and Sham)) received distilled water, while three treatment groups received oral ORIGANUM VULGARE extract for 30days (50,75 and 100 mg/kg daily, respectively). Two hours after the last dose of ORIGANUM VULGARE extract, each main group underwent a 60 min middle cerebral artery occlusion. Then, the assessment of blood BRAIN EDEMA, and NEUROLOGIC DEFICITS analysis were done. BRAIN EDEMA (brain water content) was analyzed by One-Way ANOVA using LSD method and NEUROLOGIC DEFICITS analysis by means of Mann-Whitney U, and P<0.05 was taken as the significant level.Results: ORIGANUM VULGARE extract reduced BRAIN EDEMA in the experimental groups of 50 (82.49±0.47), 75 (80.89±0.63) and 100 mg/kg/day (80.80±0.66) compared to the control group (84.46±0.67). The neurologic deficit scores in the experimental groups of 75and 100mg/kg/day, compared with control group, but neurologic deficit scores did not affect the group receiving the dose 50 mg/kg.Conclusion: The obtained data indicate that Origanum vulgar extract via reduction of BRAIN EDEMA and NEUROLOGIC DEFICITS scores can have a protective effect on the STROKE model.

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APA: Copy

FOROOZANDEH, MEYSAM, BIGDELI, MOHAMMAD REZA, & RAHNEMA, MEHDI. (2015). THE EFFECT OF PRE-NUTRITION OF HYDRO ALCOHOLIC EXTRACT OF ORIGANUM VULGARE ON BRAIN EDEMA AND NEUROLOGIC DEFICITS IN A RAT STROKE MODEL. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 22(3), 209-217. SID. https://sid.ir/paper/95432/en

Vancouver: Copy

FOROOZANDEH MEYSAM, BIGDELI MOHAMMAD REZA, RAHNEMA MEHDI. THE EFFECT OF PRE-NUTRITION OF HYDRO ALCOHOLIC EXTRACT OF ORIGANUM VULGARE ON BRAIN EDEMA AND NEUROLOGIC DEFICITS IN A RAT STROKE MODEL. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;22(3):209-217. Available from: https://sid.ir/paper/95432/en

IEEE: Copy

MEYSAM FOROOZANDEH, MOHAMMAD REZA BIGDELI, and MEHDI RAHNEMA, “THE EFFECT OF PRE-NUTRITION OF HYDRO ALCOHOLIC EXTRACT OF ORIGANUM VULGARE ON BRAIN EDEMA AND NEUROLOGIC DEFICITS IN A RAT STROKE MODEL,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 3, pp. 209–217, 2015, [Online]. Available: https://sid.ir/paper/95432/en

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