The Effect of Combined Aerobic and Resistance Exercise Training on Passive Avoidance Learning, BDNF and Ki67 Levels of Hippocampus in Wistar Rats with Different Age Groups

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Hasannejad Malome Peyman; Elmieh Alireza; Fadaie Chafi Mohammadreza

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Knowledge & Health in Basic Medical Sciences Year:2021 | Volume:16 | Issue:2 Page(s): 2-10

Download Full-Text

Persian Verion

View:

244

Download:

Cites:

Information Journal Paper

Title

The Effect of Combined Aerobic and Resistance Exercise Training on Passive Avoidance Learning, BDNF and Ki67 Levels of Hippocampus in Wistar Rats with Different Age Groups

Author(s)

Hasannejad Malome Peyman | Elmieh Alireza | Fadaie Chafi Mohammadreza | Issue Writer Certificate

Keywords

Exercise training

Hippocampal

BDNF

Abstract

Introduction: The aim of the present study was to investigate the effect of 6 weeks of combined aerobic and resistance training on passive avoidance learning, BDNF and Ki67 levels in the hippocampus of Wistar rats at different age groups. Methods: Thirty male wistar rats were prepared in three age groups of 2 weeks and 8 weeks and 24 months (n=10 in each), and each age group was divided into two groups of control and training (n=5 in each). In the training group, the animals performed resistance and aerobic training once a day. The amount of overload for the resistance training program was determined based on the body weight of the animals. For the aerobic training group, the intensity of training increased from 50% of the maximum speed in the first week to 80% in the last week. At the end of the study, passive avoidance learning was assessed by the shuttle box test. Results: The 24-month-old training group had a significant decrease in the number of round trips to darkness and light (frequency) compared to the 24-month-old control group (P<0. 05). Although BDNF mRNA level was highest in the 2-week exercise group but was not significant compared to other exercise groups at different ages (P>0. 05). Ki67 protein changes with Western blotting also showed that the 2-week age training groups and the 8-week age training group showed a significant increase compared to their control group (for both P=0. 0001). Conclusion: It seems that the older rats are less successful in behavioral tests than other ages due to more severe molecular damage in central nerve system (reduction of BDNF, Ki67), that performing combined exercise can effective in small amount.

Cites

No record.

References

No record.

Cite

APA: Copy

Hasannejad Malome, Peyman, Elmieh, Alireza, & Fadaie Chafi, Mohammadreza. (2021). The Effect of Combined Aerobic and Resistance Exercise Training on Passive Avoidance Learning, BDNF and Ki67 Levels of Hippocampus in Wistar Rats with Different Age Groups. KNOWLEDGE AND HEALTH, 16(2 ), 2-10. SID. https://sid.ir/paper/954419/en

Vancouver: Copy

Hasannejad Malome Peyman, Elmieh Alireza, Fadaie Chafi Mohammadreza. The Effect of Combined Aerobic and Resistance Exercise Training on Passive Avoidance Learning, BDNF and Ki67 Levels of Hippocampus in Wistar Rats with Different Age Groups. KNOWLEDGE AND HEALTH[Internet]. 2021;16(2 ):2-10. Available from: https://sid.ir/paper/954419/en

IEEE: Copy

Peyman Hasannejad Malome, Alireza Elmieh, and Mohammadreza Fadaie Chafi, “The Effect of Combined Aerobic and Resistance Exercise Training on Passive Avoidance Learning, BDNF and Ki67 Levels of Hippocampus in Wistar Rats with Different Age Groups,” KNOWLEDGE AND HEALTH, vol. 16, no. 2 , pp. 2–10, 2021, [Online]. Available: https://sid.ir/paper/954419/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops