THE EFFECT OF VOLUNTARY EXERCISE ON MANF LEVEL IN THE BRAINSTEM OF PARKINSONIAN RATS INDUCED BY 6-HYDROXYDOPAMINE

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FALLAH MOHAMMADI ZIA; AHMADI KORDASIABI MARJAN; AGHASI MOHAMMAD

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Journal: Journal of Birjand University of Medical Sciences Year:2014 | Volume:21 | Issue:2 Page(s): 179-187

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Title

THE EFFECT OF VOLUNTARY EXERCISE ON MANF LEVEL IN THE BRAINSTEM OF PARKINSONIAN RATS INDUCED BY 6-HYDROXYDOPAMINE

Author(s)

FALLAH MOHAMMADI ZIA | AHMADI KORDASIABI MARJAN | AGHASI MOHAMMAD | Issue Writer Certificate

Keywords

VOLUNTARY EXERCISEQ1

6Q2

HYDROXYDOPAMINEQ2

MESENCEPHALIC ASTROCYTEQ2

DERIVED NEUROTROPHIC FACTORQ2

PARKINSONQ2

RATQ2

PROTECTIVE EFFECTQ2

Abstract

Background and Aim: MESENCEPHALIC ASTROCYTE-derived neurotrophic factor (MANF) is one of neurotrophines’ family which improves the dopaminergic cells survival and activity. The purpose of the current study was to investigate the PROTECTIVE EFFECTs of 12 weeks of VOLUNTARY EXERCISE on MANF level in the brainstem of PARKINSONian RATs against the destruction of substansia nigra’s dopaminergic cells using 6-hydroxydopamine.Materials and Methods: In this experimental study, twenty-five male RATs were divided into three groups: Base (healthy control, n=9), control-Parkinson (n=9), and VOLUNTARY EXERCISE-parkinsonian (n=7). The VOLUNTARY EXERCISE control group/ healthy group (n=9) were housed in individual cages geared with running wheels and had activity for 12 weeks. To induce PARKINSON in the second group (n=9), 250 microgram in 5 microliter 6-OHDA (dissolved in saline) was administered intracerebroventricularly (ICV) using a stereotaxic apparatus.The third healthy exercise group only had VOLUNTARY EXERCISE for the same period. Finally, MANF levels in the brainstems were measured by means of ELISA. The obtained data was analyzed using one-way variance analysis (ANOVA) and Tukey post hoc.Results: Mean running distance of the subjects was 5384±764.16 meter per day. In this study MANF levels between exercise group and PARKINSON control had significant differences (P=.001). In other words, decrease in MANF levels was prevented in the exercise group (P=.001). MANF levels in the exercise group remained almost at the same level as the Base group (healthy control), P=0.615).Conclusion: VOLUNTARY EXERCISEs cause the amplification of MANF against oxidative damage induced by 6-OHDA toxicity and have a protective role against PARKINSON.

Cites

THE EFFECT OF HIGH-INTENSITY RESISTANCE EXERCISE PERIOD ON THE LEVELS OF INTERLEUKIN-10 (IL-10), TUMOR NECROSIS FACTOR-ALPHA (TNF-α), AND BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) IN THE BRAIN OF LEWIS RATS WITH EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

References

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APA: Copy

FALLAH MOHAMMADI, ZIA, AHMADI KORDASIABI, MARJAN, & AGHASI, MOHAMMAD. (2014). THE EFFECT OF VOLUNTARY EXERCISE ON MANF LEVEL IN THE BRAINSTEM OF PARKINSONIAN RATS INDUCED BY 6-HYDROXYDOPAMINE. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 21(2), 179-187. SID. https://sid.ir/paper/95507/en

Vancouver: Copy

FALLAH MOHAMMADI ZIA, AHMADI KORDASIABI MARJAN, AGHASI MOHAMMAD. THE EFFECT OF VOLUNTARY EXERCISE ON MANF LEVEL IN THE BRAINSTEM OF PARKINSONIAN RATS INDUCED BY 6-HYDROXYDOPAMINE. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;21(2):179-187. Available from: https://sid.ir/paper/95507/en

IEEE: Copy

ZIA FALLAH MOHAMMADI, MARJAN AHMADI KORDASIABI, and MOHAMMAD AGHASI, “THE EFFECT OF VOLUNTARY EXERCISE ON MANF LEVEL IN THE BRAINSTEM OF PARKINSONIAN RATS INDUCED BY 6-HYDROXYDOPAMINE,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 2, pp. 179–187, 2014, [Online]. Available: https://sid.ir/paper/95507/en

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