The effect of 8 weeks resistance exercise training on cardaic apoptosis biomarkers in diabetic rats

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MONTAZERY TALEGHANI H.; SHAKERI N.; EBRAHIM KH.; SOORI R.; GHOLAMI M.

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Journal Paper

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Journal: JOURNAL OF METABOLISM AND EXERCISE Year:2019 | Volume:9 | Issue:2 Page(s): 149-161

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Title

The effect of 8 weeks resistance exercise training on cardaic apoptosis biomarkers in diabetic rats

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Keywords

Type 2 diabetes

Apoptosis

Resistance exercise

Gene expression

Abstract

Aim: A main reason of death in diabetes is cardiovascular diseases, which Apoptosis plays a critical role through the progress. As known, physical activity can protect human heart from damaging induced by Apoptosis. This study was investigate the effects of eight weeks of Resistance exercises on cardiomyocyte Apoptosis markers in diabetic rats. Method: twenty male wistar rats (8 weeks old and 210-250 g weight) were randomly allocated into two groups. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg) in diabetic groups. The resistance training carried out on a step ladder, with an 80% slope and a load of 30-100 percentage of subjects weight, whereas control group remained sedentary. To determine training adaptations, blood and heart tissue samples were taken. The level of the serum glucose, insulin, insulin resistance index, and Gene expression levels Bcl-2, Bax, caspase8 and the ratio of Bax/ Bcl-2 were assessed. Results: Implementation of 8 weeks of Resistance exercise resulted significant decrease in Gene expression levels Bax and the ratio of bax/ Bcl-2 (p=0/000) and a significant increase in Bcl-2 (p=0/000) and caspase 8 (p=0/004) compare to control group. Conclusion: The results show that Resistance exercise may be used as a non‐ pharmacological strategy to reduce side effects of Apoptosis in the heart cells in diabetes.

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APA: Copy

MONTAZERY TALEGHANI, H., SHAKERI, N., EBRAHIM, KH., SOORI, R., & GHOLAMI, M.. (2019). The effect of 8 weeks resistance exercise training on cardaic apoptosis biomarkers in diabetic rats. JOURNAL OF METABOLISM AND EXERCISE, 9(2 ), 149-161. SID. https://sid.ir/paper/955287/en

Vancouver: Copy

MONTAZERY TALEGHANI H., SHAKERI N., EBRAHIM KH., SOORI R., GHOLAMI M.. The effect of 8 weeks resistance exercise training on cardaic apoptosis biomarkers in diabetic rats. JOURNAL OF METABOLISM AND EXERCISE[Internet]. 2019;9(2 ):149-161. Available from: https://sid.ir/paper/955287/en

IEEE: Copy

H. MONTAZERY TALEGHANI, N. SHAKERI, KH. EBRAHIM, R. SOORI, and M. GHOLAMI, “The effect of 8 weeks resistance exercise training on cardaic apoptosis biomarkers in diabetic rats,” JOURNAL OF METABOLISM AND EXERCISE, vol. 9, no. 2 , pp. 149–161, 2019, [Online]. Available: https://sid.ir/paper/955287/en

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