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Information Journal Paper

Title

The effect of high intensity interval training on myostatin and SMAD2/3 proteins in the left ventricular tissue of the heart muscle of type 1 diabetic rats

Pages

  21-30

Abstract

 Background and Objective: Disruption of the myostatin/SMAD pathway can lead to heart failure. Diabetes can disrupte this pathway. Therefore, the present study aimed to evaluate the effect of six weeks of high-intensity interval training HIIT (on myostatin and SMAD2/3 proteins in the left ventricular tissue of the heart muscle of type 1 diabetic rats. Materials and Methods: In this study, 12 Spragodoli male rats (2-month old) with a mean weight of 300± 20 g were selected. Through streptozotocin solution, they were randomly divided into 2 groups: diabetic endurance training (6 heads) and diabetic control (6 heads); The training groups performed the training program 4 days a week for 6 weeks, including 5 interval 4-minute with an intensity of 85 to 95% of the maximum speed, and 3-minute active rest periods with an intensity of 50 to 60% of the maximum speed; Independent t-test was used to analyze the data. Results: Six weeks of HIIT training lead to a significant reduction in Myostatin protein content between training and control groups in myocardial tissue (P=0. 044). Also, HIIT training resulted in a significant decrease in SMAD2/3 protein content between training and control groups in myocardial tissue (P=0. 001). Conclusion: It can be said that HIIT training by reducing the content of myostatin and SMAD2/3 proteins in the left ventricle of the heart has been able to prevent cardiac atrophy in type 1 diabetic subjects. This reduction can lead to physiological cardiac hypertrophy.

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    APA: Copy

    JOKAR, MASOUD, SHERAFATI MOGHADAM, MOHAMMAD, & Amirahmadi, Mousa. (2021). The effect of high intensity interval training on myostatin and SMAD2/3 proteins in the left ventricular tissue of the heart muscle of type 1 diabetic rats. DANESHVAR MEDICINE, 29(153 ), 21-30. SID. https://sid.ir/paper/955477/en

    Vancouver: Copy

    JOKAR MASOUD, SHERAFATI MOGHADAM MOHAMMAD, Amirahmadi Mousa. The effect of high intensity interval training on myostatin and SMAD2/3 proteins in the left ventricular tissue of the heart muscle of type 1 diabetic rats. DANESHVAR MEDICINE[Internet]. 2021;29(153 ):21-30. Available from: https://sid.ir/paper/955477/en

    IEEE: Copy

    MASOUD JOKAR, MOHAMMAD SHERAFATI MOGHADAM, and Mousa Amirahmadi, “The effect of high intensity interval training on myostatin and SMAD2/3 proteins in the left ventricular tissue of the heart muscle of type 1 diabetic rats,” DANESHVAR MEDICINE, vol. 29, no. 153 , pp. 21–30, 2021, [Online]. Available: https://sid.ir/paper/955477/en

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