CORRELATION BETWEEN PARAOXONASE/ARYLESTERASE ENZYME ACTIVITIES AND SERUM LIPID CONCENTRATIONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AFZALPOUR M.E.; GHARAKHANLOU R.; GAEINI A.A.; SEGHAT ALESLAM A.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Birjand University of Medical Sciences Year:2006 | Volume:12 | Issue:3-4 (24-25) Page(s): 29-35

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,010

Download:

Cites:

Information Journal Paper

Title

CORRELATION BETWEEN PARAOXONASE/ARYLESTERASE ENZYME ACTIVITIES AND SERUM LIPID CONCENTRATIONS

Author(s)

AFZALPOUR M.E. | GHARAKHANLOU R. | GAEINI A.A. | SEGHAT ALESLAM A. | Issue Writer Certificate

Keywords

PARAOXONASE ENZYMEQ4

ARYL ESTERASE ENZYMEQ4

SERUM LIPID CONCENTRATIONSQ4

HEALTHY MENQ3

Abstract

Background and Aim: Human serum paraoxonase (PON) / aryl esterase (ARE) is synthesized by the liver and its roles are hydrolysis of organophosphate compounds in mammals and resistance against atherosclerosis. This enzyme has tree model phenotypes-distribution, including AA (homozygous with low activity), AB (heterozygous with Average activity), or BB (homozygous with high activity). This study was aimed to measure the level of PON/ARE activity and determine the relationship between activity of this enzymeand serum lipid levels& non-lipid indices in 25-50 year-old HEALTHY MEN.Materials and Methods: Our research was a sectional and observational study. Fifty HEALTHY MEN from Tarbiat Moddares University were volunteered for this research. PNO activity was measured by a spectrophotometric method using 1 ml serum; adding Immol TrislHCL buffer including 2 mmol/L calcium chloride and 5.5 mmol/L HCL. Paranitrophenol production was measured at 405 nm wave length. ARE was determined by adding serum to 20 ml buffer including 1 mmol/L calcium chloride and 1 mmol/L phenyl acetate. Phenotype distribution was estimated by two substrates method. The correlation between PON/ARE activities and lipid & non-lipid indices were evaluated by Pearson correlation analysis. We used 2-tailed Pvalues. The P<0.05 was accepted as the level of significance.Results: The average activities of PON and ARE were 89.14±40.62 and 100.15±36.16UIL, respectively.This means that our participants had lower enzyme activity and all of them classified as AA phenotype. There were no significant correlations between PON/ARE activity and demographic characteristics (age, body mass index, waist to hip ratio or blood pressure). In addition, there were no significant correlations between PON/ARE activity and lipid indices (triglyceride, total cholesterol, LDL & HDL). However, LDL /PON ratio had a significant relationship with HDL/LDL ratio(r=-0.45, P<0.002), HDL/total cholesterol ratio (r=-0.37, P<0.01), total cholesterol concentration(r=0.34, P<0.02), and LDL concentration (r=0.46, P<0.001).Conclusion: Existence of weak correlation between serum PON/ARE activities and lipid indices along with low PON activity in studied group suggest that PON/ARE enzyme activities are under influence of genetic and racial factors.

Cites

No record.

References

No record.

Cite

APA: Copy

AFZALPOUR, M.E., GHARAKHANLOU, R., GAEINI, A.A., & SEGHAT ALESLAM, A.. (2006). CORRELATION BETWEEN PARAOXONASE/ARYLESTERASE ENZYME ACTIVITIES AND SERUM LIPID CONCENTRATIONS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 12(3-4 (24-25)), 29-35. SID. https://sid.ir/paper/95555/en

Vancouver: Copy

AFZALPOUR M.E., GHARAKHANLOU R., GAEINI A.A., SEGHAT ALESLAM A.. CORRELATION BETWEEN PARAOXONASE/ARYLESTERASE ENZYME ACTIVITIES AND SERUM LIPID CONCENTRATIONS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;12(3-4 (24-25)):29-35. Available from: https://sid.ir/paper/95555/en

IEEE: Copy

M.E. AFZALPOUR, R. GHARAKHANLOU, A.A. GAEINI, and A. SEGHAT ALESLAM, “CORRELATION BETWEEN PARAOXONASE/ARYLESTERASE ENZYME ACTIVITIES AND SERUM LIPID CONCENTRATIONS,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 12, no. 3-4 (24-25), pp. 29–35, 2006, [Online]. Available: https://sid.ir/paper/95555/en

Related Journal Papers