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Information Journal Paper

Title

The Histological Changes in Endocrine Part of the Pancreas of Diabetic Rats Treated with Rosa Damascena Extract

Pages

  383-389

Abstract

 Background: Diabetes is caused by a breakdown in Insulin production or its malfunction in the body. So far, many studies have been done on its treatment. The aim of this study was to investigate the histological changes in endocrine part of the pancreas of diabetic rats treated with Rosa damascena extract. Methods: In this experimental study, 100 male rats were divided into 10 groups of control, untreated diabetic, gavage stress, Insulin treatment, three healthy groups receiving different doses of extract, and three diabetic groups receiving different doses of extract (300, 600, and 900 mg/kg). Finally, pancreatic tissue was removed and immunohistochemically stained with hematoxylin-eosin to count pancreatic beta cells number, and to calculate islets of Langerhans. Statistical analysis was performed using ANOVA test, and P < 0. 050 was considered as statistically significant. Findings: Rosa damascena extract at 900 mg/kg, significantly increased the area of the islets of Langerhans in diabetic rats compared to the diabetic control group (P = 0. 021). This dose of extract also increased the percentage of beta cells in the islets of Langerhans compared to the diabetic control group (P = 0. 017). Conclusion: According to the results, using rose extract can improve tissue changes in the pancreas. This extract can probably be considered as a suitable research potential in future studies.

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    APA: Copy

    ESFANDIARI, EBRAHIM, Rouhollahi, Shima, Ghanadian, Sayed Mostafa, RASHIDI, BAHMAN, & MOSTAFAVI, FATEMEH SADAT. (2020). The Histological Changes in Endocrine Part of the Pancreas of Diabetic Rats Treated with Rosa Damascena Extract. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 38(578 ), 383-389. SID. https://sid.ir/paper/955733/en

    Vancouver: Copy

    ESFANDIARI EBRAHIM, Rouhollahi Shima, Ghanadian Sayed Mostafa, RASHIDI BAHMAN, MOSTAFAVI FATEMEH SADAT. The Histological Changes in Endocrine Part of the Pancreas of Diabetic Rats Treated with Rosa Damascena Extract. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2020;38(578 ):383-389. Available from: https://sid.ir/paper/955733/en

    IEEE: Copy

    EBRAHIM ESFANDIARI, Shima Rouhollahi, Sayed Mostafa Ghanadian, BAHMAN RASHIDI, and FATEMEH SADAT MOSTAFAVI, “The Histological Changes in Endocrine Part of the Pancreas of Diabetic Rats Treated with Rosa Damascena Extract,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 38, no. 578 , pp. 383–389, 2020, [Online]. Available: https://sid.ir/paper/955733/en

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